Results 81 to 90 of about 33,945,293 (343)

Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach

Health and Quality of Life Outcomes, 2017
Background There are diverse opinions and confusion about defining and including patient values and preferences (i.e. the importance people place on the health outcomes) in the guideline development processes.
Yuan Zhang, Pablo Alonso Coello, Jan Brożek, Wojtek Wiercioch, Itziar Etxeandia-Ikobaltzeta, Elie A. Akl, Joerg J. Meerpohl, Waleed Alhazzani, Alonso Carrasco-Labra, Rebecca L. Morgan, Reem A. Mustafa, John J. Riva, Ainsley Moore, Juan José Yepes-Nuñez, Carlos Cuello-Garcia, Zulfa AlRayees, Veena Manja, Maicon Falavigna, Ignacio Neumann, Romina Brignardello-Petersen, Nancy Santesso, Bram Rochwerg, Andrea Darzi, Maria Ximena Rojas, Yaser Adi, Claudia Bollig, Reem Waziry, Holger J. Schünemann   +27 more
doaj   +1 more source

Methods [PDF]

, 2006
Information assembled in this chapter will help the reader understand the basis for the preliminary conclusions of the Expedition 302 Scientists and will also enable the interested investigator to select samples for further analyses. This information concerns offshore and onshore operations and analyses described in the "Sites M0001–M0004" chapter ...
Backman, J., Moran, K., McInroy, D., Brinkhuis, H.K., Clemens, S., Cronin, T., Dickens, G.R., Eynaud, F., Gattacceca, J., Jakobsson, M., Jordan, R.W., Kaminski, M., King, J., Koç, N., Martinez, N.C., Matthiessen, J., Moore, T.C., Onodera, J., O'Regan, M., Pälike, H., Rea, B.R., Rio, D., Sakamoto, T., Smith, D.C., Stein, R., St. John, K.E.K., Suto, I., Suzuki, N., Takahashi, K., Watanabe, M., Yamamoto, M.   +30 more
openaire   +3 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

SpiderPhy dataset: A multimodal dataset of Physiological, Psychometric and Behavioral Responses to fear stimuli

Scientific Data
The SpiderPhy dataset is a dataset of physiological, psychometric, and behavioral data from subclinical spider fearful individuals (N = 54) who underwent exposure to spider stimuli.
Cindy S. Lor, David Steyrl, Alexander Karner, Sebastian J. Götzendorfer, Anne Klimesch, Stephanie J. Eder, Fabian M. Renz, Johannes Rother, Frank Scharnowski, Filip Melinscak   +9 more
doaj   +1 more source

Statistical methods in cosmology

, 2009
The advent of large data-set in cosmology has meant that in the past 10 or 20 years our knowledge and understanding of the Universe has changed not only quantitatively but also, and most importantly, qualitatively.
A. F. Heavens, A. F. Heavens, A. Kosowsky, A. O’Hagan, A. R. Liddle, A. Stuart, A. Stuart, D. J. Eisenstein, D. N. Spergel, D. N. Spergel, G. Schwarz, H. Akaike, H. Seo, H. Seo, J. Hamann, J. P. Wall, L. Verde, L. Verde, M. Kowalski, R.A. Fisher, S. Cole, V. J. Martinez, W. Cash, W. H. Press, W. J. Percival, W. Percival   +25 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

Journal of Analytical Methods in Chemistry, 2021
Journal of Analytical Methods in Chemistry
doaj   +1 more source

Features of databases that supported searching for rapid evidence synthesis during COVID-19: implications for future public health emergencies

BMC Medical Research Methodology
Background As evidence related to the COVID-19 pandemic surged, databases, platforms, and repositories evolved with features and functions to assist users in promptly finding the most relevant evidence. In response, research synthesis teams adopted novel
Leah Hagerman, Emily C. Clark, Sarah E. Neil-Sztramko, Taylor Colangeli, Maureen Dobbins   +4 more
doaj   +1 more source

Method

, 2018
[FR] L'invention concerne des agents chimioluminescents ciblant les mitochondries et leur utilisation dans des méthodes de thérapie photodynamique (PDT). En particulier, l'invention concerne des composés de formule générale (I), et leurs sels pharmaceutiquement acceptables : (I) dans laquelle A représente une fraction chimioluminescente ; chaque L, qui
Vougioukalakis, G.C., Rotas, G., Theodossiou, T., Berg, Kristian, Miranda, M. A.   +4 more
openaire   +3 more sources

Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1

FEBS Letters, EarlyView.
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri, Andrea Lapucci, Giuseppe Orsomando, Nadia Raffaelli, Alberto Chiarugi, Daniela Buonvicino   +5 more
wiley   +1 more source