Results 91 to 100 of about 3,768,575 (328)

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

open access: yesFEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López   +2 more
wiley   +1 more source

Theory and method

open access: yesInnovative Project, 2017
The article discusses the difference between different approaches to architectural theory: born from individual design practice, from that based on the construction of a fundamentally new picture of design and architectural activity. The differences between end-result-oriented theories and theories that presuppose constant self-restructuring are ...
Lars H. Gulbrandsen   +3 more
openaire   +2 more sources

Le sens ou la preuve ? D’une conception de la pratique à une épistémologie des pédagogies alternatives

open access: yesRecherches en Éducation
The contributors to this issue of REE magazine were invited to give an account of their research on alternative pedagogies. This synthesis attempts to identify the common features of these texts in epistemological and methodological terms, as well as in ...
Sébastien Pesce, Bruno Robbes
doaj   +1 more source

Gauge theory duals of black hole - black string transitions of gravitational theories on a circle [PDF]

open access: yes, 2010
We study the black hole - black string phase transitions of gravitational theories compactified on a circle using the holographic duality conjecture.
Catterall, Simon   +2 more
core   +2 more sources

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Renewing Theories, Methods and Design Practices: Challenges for Architectural Education

open access: yesSHS Web of Conferences, 2018
Architectural education should promote the advancement of knowledge that is necessary as the basis for the development of excellent design practice. Architectural education needs to respond appropriately to the current issues in the society.
Andri Yatmo Yandi
doaj   +1 more source

BRST Quantisation and the Product Formula for the Ray-Singer Torsion

open access: yes, 1993
We give a quantum field theoretic derivation of the formula obeyed by the Ray-Singer torsion on product manifolds. Such a derivation has proved elusive up to now.
Connor, Denjoe O', Nash, Charles
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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