Results 131 to 140 of about 672,794 (243)

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Diagnostic Approach and Therapeutic Management of Spontaneous Esophageal Perforation (Boerhaave's Syndrome): A Systematic Review and Individual Patient-Level Pooled Analysis. [PDF]

J Clin Med
Mela E, Frountzas M, Tomara N, Damaskos D, Karangeli N, Mylonakis A, Despotidis M, Sourgiadakis A, Dimitriou N, Tribonias G, Schizas D.   +10 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Exosomes as Molecular Mediators of Reproductive Health: From Infertility to HPV-Related Disease. [PDF]

Curr Issues Mol Biol
Siourtou SN, Stavros S, Daskalaki MA, Kokkosi E, Zikopoulos A, Mavrogianni D, Kalogerakou V, Karampitsakos T, Moustakli E, Arkouli N, Potiris A, Daskalakis G, Drakakis P.   +12 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Mycobacteriophages: An Integrated Platform for Rapid Diagnosis and Targeted Therapy of Tuberculosis Infection. [PDF]

Microorganisms
Avdeev VV, Vladimirsky MA, Eliseev PI, Samoilova AG, Nikitina NA, Tiulkova TE, Vasilyeva IA.   +6 more
europepmc   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

MicroRNAs in Cutaneous Melanoma: Biological Roles, Clinical Utility, and Future Directions. [PDF]

Med Sci (Basel)
Pașcu AI, Muntean MV, Gherman CD, Gâta VA, Şenila SC, Halmágyi SR, Ungureanu L.   +6 more
europepmc   +1 more source

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

Mapping the Expression Profile of MicroRNA in Peri-Implantitis: A Scoping Review. [PDF]

Int J Dent
Muruganandam M, Nayak SU, Uppoor AS, Gupta A, Kumar S.   +4 more
europepmc   +1 more source