Results 161 to 170 of about 1,049,189 (292)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

From magma ocean to core-mantle boundary: the key role of hydrous ferropericlase in shaping deep Earth's low-velocity anomalies. [PDF]

Natl Sci Rev
Guan SD, Wang Y, Du ZX, Yang YN, Xu YG.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Granitic intrusions enhance strain localization and rapid mantle exhumation along an oceanic detachment fault. [PDF]

Sci Adv
Poulaki EM, Bickert M, Vannucchi P, Shuck BD, Akizawa N, Pandey A, Morishita T, Sanfilippo A, Cunningham EH, Barnes JD, Garber JM, Nistor C, Bernard R, Tribuzio R, Loocke M, Abe N, Di Stefano A, Filina IY, Fu Q, Gontharet SBL, Kearns LE, Koorapati RK, Lei C, Loreto MF, Magri L, Menapace W, Pavlovics VL, Pezard PA, Rodriguez-Pilco MA, Zhao X, Pérez-Gussinyé M, Garrido CJ, Ranero CR, Estes ER, Malinverno A, Zitellini N.   +35 more
europepmc   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Distance learning as a new method for studying the earth sciences in high school

, 2003
The aim of this research was to develop a computerized distance-learning unit that will fit the needs of the Israeli high-school earth-science syllabus. the ability of students to conduct lab-activities as a part of a distance-learning unit was the main focus of this study. As part of this work, a web- site was developed for this course.
Gudovitch, Y., Orion, N., Gudovitch, Y., Orion, N.   +3 more
openaire   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Observational constraints from global ice-phase fraction indicate moderate climate sensitivity. [PDF]

Sci Adv
Zhou R, Dou T, Zhou C, Tan I, Chen D, Xu G, Yang Y, Gong X, Ju X, Wang A, Xiao C.   +10 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Responses of China's dry grassland low-growth to temperature- and water-related extremes. [PDF]

iScience
Zhou S, Zhao Z, Wang L, Chen D, Li X, Luo D.   +5 more
europepmc   +1 more source