Results 161 to 170 of about 20,506,520 (292)

Study team perspectives on a multisite randomized clinical trial with underserved rural populations: A mixed methods feasibility analysis. [PDF]

PLoS One
Foster KL, Sanders S, Madden CA, Malloch L, Swango-Wilson A, Jandasek B, Garza MY, Baldner J, Dawley E, VanWagoner T, Saul JP, Davis AM.   +11 more
europepmc   +1 more source

Meiotic crossover interference: Methods of analysis and mechanisms of action. [PDF]

Curr Top Dev Biol, 2023
Chuang YC, Smith GR.
europepmc   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

A national review of NHS policies and patient perspectives on surgical video: a prospective, mixed methods qualitative analysis. [PDF]

EClinicalMedicine
Yiu A, Lam K, Simister C, Silver A, Hicks C, Vass M, Kinross J.   +6 more
europepmc   +1 more source

Basket trials in oncology: a systematic review of practices and methods, comparative analysis of innovative methods, and an appraisal of a missed opportunity. [PDF]

Front Oncol, 2023
Kasim A, Bean N, Hendriksen SJ, Chen TT, Zhou H, Psioda MA.   +5 more
europepmc   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Understanding Patient Perceptions of Bacterial Vaginosis Treatments: Mixed Methods Sentiment Analysis Study of Online Drug Review Forums. [PDF]

Online J Public Health Inform
Watkins E, Cimino AN, Culbertson C, Raymaker J, Amico JR.   +4 more
europepmc   +1 more source

Natural Carotenoids: Recent Advances on Separation from Microbial Biomass and Methods of Analysis. [PDF]

Antioxidants (Basel), 2023
Papapostolou H, Kachrimanidou V, Alexandri M, Plessas S, Papadaki A, Kopsahelis N.   +5 more
europepmc   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Beyond one-size-fits-all: leveraging mixed-methods qualitative analysis of local stakeholders to tailor validated prehospital care solutions in the Cameroonian cultural context. [PDF]

BMJ Open
OConnor K, Hayashi A, Tabe V, Dissak-Delon FN, Nsen L, Joel M, Tanue EA, Oke R, Delaney PG, Eisner Z, Chichom Mefire A, Juillard C, Christie AS.   +12 more
europepmc   +1 more source