Results 181 to 190 of about 4,400 (219)

Graph neural networks for single-cell omics data: a review of approaches and applications. [PDF]

Brief Bioinform
Li S, Hua H, Chen S.
europepmc   +1 more source

Decoding the Cardiac Immune Microenvironment and Fibroblast Crosstalk in Radiotherapy Combined with Immunotherapy‐Induced Cardiac Fibrosis Based on Single‐Cell Transcriptomic Analysis

Advanced Science, EarlyView.
This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo, Ying Yu, Zhimin Zeng, Yanxin Chen, Yali Yi, Zhiqin Lu, Fujuan Zeng, Peng Xu, Daya Luo, Leifeng Chen, Anwen Liu   +10 more
wiley   +1 more source

Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution. [PDF]

Protein Cell
Lu P, Zhang Y, Cui Y, Liao Y, Liu Z, Cao ZJ, Liu JE, Wen L, Zhou X, Fu W, Tang F.   +10 more
europepmc   +1 more source

Selenoprotein H Functions as a PPARα Coactivator to Link Selenium Homeostasis to Hepatic Lipid Metabolism and Protect against Steatohepatitis

Advanced Science, EarlyView.
Our study identifies selenium deficiency as a hallmark of MASH pathogenesis. Dietary selenium supplementation enhances hepatic fatty acid oxidation (FAO) and attenuates MASH progression by activating the PPARα pathway via selenoprotein H (SELENOH). This selenium‐SELENOH‐PPARα nexus redefines the functional scope of selenoproteins, moving from redox ...
Yuwei Zhang, Yuchen Wang, Binbin Li, Xin Li, Chenyu Liu, Yanhao Chen, Cheng Tian, Dongmei Wang, Xiaosong Gu, Chunping Jiang, Yuda Wei, Qiurong Ding   +11 more
wiley   +1 more source

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Organoids and organoid extracellular vesicles-based disease treatment strategies. [PDF]

J Nanobiotechnology
Zhou G, Li R, Sheng S, Huang J, Zhou F, Wei Y, Liu H, Su J.   +7 more
europepmc   +1 more source

Application of AI and digital health tools in public health management of T2DM: from mechanism prediction to personalized treatment. [PDF]

Front Public Health
Yu C.
europepmc   +1 more source

The role of leadership identity in business and public sectors: a content analysis approach. [PDF]

Front Psychol
Engin S, Kasap F.
europepmc   +1 more source

"Multi-layer" encryption of medical data in DNA for highly-secure storage. [PDF]

Mater Today Bio
Xu J, Wang Y, Chen X, Wang L, Zhou H, Mei H, Chen S, Huang X.   +7 more
europepmc   +1 more source