Results 181 to 190 of about 4,413 (218)

Enzymatic DNA Reaction Networks for Orchestrating Stimuli‐Dependent Temporal Molecular Pulse

Advanced Science, EarlyView.
We present an enzymatic DNA reaction network (EDRN) that encodes nucleic‐acid targets in time, converting inputs into a universal strand and then into programmable transient fluorescence pulses. With time‐color multiplexing, EDRN enables single‐tube high‐plex nucleic acid detection and shows strong agreement with clinical sequencing across 32 specimens.
Jiayu Yang, Yali Chang, Zibin Chu, Linghao Zhang, Tengfang Zhang, Dai Erhei, Xin Su, Zhe Yin   +7 more
wiley   +1 more source

Ammonia Detoxification Inhibits Liver Metastasis by Reshaping Hepatic Microenvironment

Advanced Science, EarlyView.
Liver metastasis diverts aspartate into hyperactive pyrimidine synthesis, disrupting urea cycling and causing pathogenic ammonia accumulation. Ammonia dually reprograms the microenvironment by: (1) activating hepatic stellate cells (HSCs) into pro‐fibrotic metastasis‐associated fibroblasts (MAFs), and (2) suppressing anti‐tumor monocytes/macrophages ...
Sumin Sun, Haili Hu, Long Chen, Yuan Gao, Peng Sun, Liming Chen   +5 more
wiley   +1 more source

Genome-wide DNA methylation analysis of <i>Medicago sativa</i> L. treated with plasma and plasma-activated water. [PDF]

iScience
Xu F, Chen H, Chen C, Liu J, Song Z, Ding C.   +5 more
europepmc   +1 more source

Recent Advances in Laser‐Induced Graphene‐Based Gas Sensors: From Sensing Mechanisms to Biomedical Applications

Advanced Science, EarlyView.
Laser‐induced graphene (LIG) provides a scalable, laser‐direct‐written route to porous graphene architecture with tunable chemistry and defect density. Through heterojunction engineering, catalytic functionalization, and intrinsic self‐heating, LIG achieves highly sensitive and selective detection of NOX, NH3, H2, and humidity, supporting next ...
Md Abu Sayeed Biswas, Ankan Dutta, Shuvendu Das, Abu Musa Abdullah, Wanqing Zhang, Fatema Tuz Zohra, Huanyu Cheng   +6 more
wiley   +1 more source

Mapping immune cell dynamics and macrophage plasticity in breast cancer tumor microenvironment through single-cell analysis. [PDF]

Discov Oncol
Chen W, Zeng S, Zhong J, Zou J, Lei Y, Chen X, Mei Q, Luo Q.   +7 more
europepmc   +1 more source

Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Graph neural networks for single-cell omics data: a review of approaches and applications. [PDF]

Brief Bioinform
Li S, Hua H, Chen S.
europepmc   +1 more source

Systematic characterization of full-length RNA isoforms in human colorectal cancer at single-cell resolution. [PDF]

Protein Cell
Lu P, Zhang Y, Cui Y, Liao Y, Liu Z, Cao ZJ, Liu JE, Wen L, Zhou X, Fu W, Tang F.   +10 more
europepmc   +1 more source

Organoids and organoid extracellular vesicles-based disease treatment strategies. [PDF]

J Nanobiotechnology
Zhou G, Li R, Sheng S, Huang J, Zhou F, Wei Y, Liu H, Su J.   +7 more
europepmc   +1 more source

Application of AI and digital health tools in public health management of T2DM: from mechanism prediction to personalized treatment. [PDF]

Front Public Health
Yu C.
europepmc   +1 more source