Results 21 to 30 of about 166,173,374 (180)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Decipherment of the Indus script [PDF]

, 2020
This paper describes a decipherment of the Indus script. The decipherment is based on observed similarities between Protocuneiform script and the Indus script.
Ramkumar Unnipillai Santhakumari
core   +2 more sources

A Cryptanalytic Test of the Phaistos Disc as a Protein Sequence

Cryptography
The Phaistos Disc is an undeciphered Minoan-era artifact bearing 242 stamped occurrences of 45 distinct signs. We test whether it encodes one or more protein sequences, with each sign representing an amino acid or post-translationally modified amino acid
Federico M. Giorgi, Fabrizio Baldacci
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

Advanced Techniques for the Decipherment of Ancient Scripts [PDF]

, 2022
This contribution explores modern and traditional approaches to the decipherment of ancient writing systems. It surveys methods used by paleographers and epigraphers and state-of-the art applications of computational linguistics, such as models based on ...
Ferrara S., Tamburini F.
core   +1 more source

“Wandering in the Worlds” by B. Kairbekov: the Role of Autometatext in the Interpretation of a Translingual Work

RUDN Journal of Language Studies, Semiotics and Semantics
Due to its heterogeneous nature, a translingual literary text causes certain difficulties for research. Being created by the author in a language that is not ethnically primary for him, it contains both exophonic elements marking its foreign cultural ...
Karlygash E. Nurmaganbet, Vladimir P. Sinyachkin, Ainur O. Azizova, Alyona S. Demchenko   +3 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Records, Writing, and Decipherment [PDF]

, 1974
Written records together with material remains derived from excavations form the main bases for our understanding of past civilizations and their underlying language systems.
Gelb, I. J.
core  

Topo-Diff: a topology-guided diffusion model for oracle bone script transformation

Shenzhen Daxue xuebao. Ligong ban
Aiming at the difficulties in accurate decipherment and digital restoration of oracle bone scripts (OBSs) caused by carrier damage, severe noise interference and glyph variations, we propose a topology-guided diffusion model named Topo-Diff.
Liu Guangnan, Qin Guangjun, Yang Zixuan, Wu Mengjie, Liang Xiaoyun   +4 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source