Results 41 to 50 of about 286,599 (266)
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
The Market Concept of the 21st Century: a New Approach to Consumer Segmentation
Vestnik MGIMO-Universiteta, 2016 World economic development in the 21st century keeps tendencies and contradictions of the previous century. Economic growth in a number of the countries and, as a result, growth of consumption adjoins to an aggravation of global problems of the present ...
Maria Igorevna Sokolova
doaj
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
The Klein Doctrine: The Rise of Disaster Polemics [PDF]
, 2008 Naomi Klein's The Shock Doctrine purports to be an expose of the ruthless nature of free-market capitalism and its chief recent exponent, Milton Friedman.
Johan Norberg
core
Out-of-pocket payments for health care services in Bulgaria: financial burden and barrier to access.
, 2012 BACKGROUND: In recent years, Bulgaria has increasingly relied on out-of-pocket payments as one of the main sources of health care financing. However, it is largely unknown whether the official patient charges, combined with informal payments, are ...
Atanasova, Elka +4 more
core +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
The Market Concept of the 21 Century: a New Approach to Consumer Segmentation
Vestnik MGIMO-Universiteta, 2016 World economic development in the 21st century keeps tendencies and contradictions of the previous century. Economic growth in a number of the countries and, as a result, growth of consumption adjoins to an aggravation of global problems of the present ...
Maria Igorevna Sokolova
doaj
Evaluation of a learner-designed course for teaching health research skills in Ghana
BMC Medical Education, 2007 Background In developing countries the ability to conduct locally-relevant health research and high quality education are key tools in the fight against poverty.
Agbenyega Tsiri +6 more
doaj +1 more source
Molecular Oncology, EarlyView.This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian +10 more
wiley +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source