Results 311 to 320 of about 271,187 (352)
Some of the next articles are maybe not open access.
Clinical and experimental rheumatology, 2010
The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
openaire +3 more sources
The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
openaire +3 more sources
Current Opinion in Rheumatology, 2009
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about three decades now. MTX is one of the most effective and commonly used medicines to treat various forms of arthritis and other rheumatic conditions. MTX was shown to improve signs and symptoms of RA, disease activity and function, to a similar degree as the tumor ...
Juergen Braun, Rolf Rau
openaire +2 more sources
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about three decades now. MTX is one of the most effective and commonly used medicines to treat various forms of arthritis and other rheumatic conditions. MTX was shown to improve signs and symptoms of RA, disease activity and function, to a similar degree as the tumor ...
Juergen Braun, Rolf Rau
openaire +2 more sources
Annals of Internal Medicine, 1969
Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
openaire +3 more sources
Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
openaire +3 more sources
ChemInform Abstract: ANALOGUES OF METHOTREXATE
Chemischer Informationsdienst, 1979AbstractÜber eine Alkylierung mit 6‐(Brommethyl)‐2,4‐pteridindiamin und Analoge und (teilweise) Verseifung werden die Verbindungen (II) bis (V) in Ausbeuten bis zu 97% dargestellt.
Carroll Temple +5 more
openaire +4 more sources
Pharmacokinetics of 7‐Hydroxy‐methotrexate and Methotrexate in the Rat
Pharmacology & Toxicology, 1988Abstract: To investigate the pharmacokinetics of the active metabolite of methotrexate (MTX), 7‐hydroxy‐methotrexate (7‐OH‐MTX), 1 mg/kg of the compound was administered as single intravenous bolus injections to 6 unanaestetized rats. For comparison, 1 mg/kg of the parent drug MTX was given to the same number of animals.
Jarle Aarbakke +3 more
openaire +3 more sources
JAMA: The Journal of the American Medical Association, 1973
The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
openaire +3 more sources
The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
openaire +3 more sources
The pharmacology of methotrexate
Journal of the American Academy of Dermatology, 1991Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population.
openaire +3 more sources