Results 341 to 350 of about 369,868 (397)
Some of the next articles are maybe not open access.
International Journal of Radiation Oncology*Biology*Physics, 1978
INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
openaire +2 more sources
INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
openaire +2 more sources
The Journal of Dermatology, 1999
AbstractMethotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, e.g., dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis.
K A, Jang +5 more
openaire +2 more sources
AbstractMethotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, e.g., dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis.
K A, Jang +5 more
openaire +2 more sources
Dermatologic Therapy, 2007
Methotrexate is a folic acid analog pioneered for use in inflammatory diseases by dermatologists, and used successfully for over 40 years for a wide variety of cutaneous diseases. In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related to its effects on adenosine.
Carolyn A, Bangert, Melissa I, Costner
openaire +2 more sources
Methotrexate is a folic acid analog pioneered for use in inflammatory diseases by dermatologists, and used successfully for over 40 years for a wide variety of cutaneous diseases. In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related to its effects on adenosine.
Carolyn A, Bangert, Melissa I, Costner
openaire +2 more sources
Clinical and experimental rheumatology, 2010
The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
openaire +3 more sources
The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
openaire +3 more sources
Journal of Allergy and Clinical Immunology, 1991
Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
openaire +2 more sources
Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
openaire +2 more sources
Current Opinion in Rheumatology, 2001
Methotrexate and leflunomide are both effective drugs in the treatment of patients with rheumatoid arthritis. Methotrexate has been available for many years, whereas leflunomide is a relatively new drug. Several large trials describing its efficacy and safety in comparison with both sulfasalazine and methotrexate and with placebo have been published ...
Laan, R.F.J.M. +2 more
openaire +3 more sources
Methotrexate and leflunomide are both effective drugs in the treatment of patients with rheumatoid arthritis. Methotrexate has been available for many years, whereas leflunomide is a relatively new drug. Several large trials describing its efficacy and safety in comparison with both sulfasalazine and methotrexate and with placebo have been published ...
Laan, R.F.J.M. +2 more
openaire +3 more sources
Annals of Internal Medicine, 1969
Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
openaire +2 more sources
Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
openaire +2 more sources
Skeletal Radiology, 1984
Methotrexate osteopathy is an uncommon complication of long-term oral maintenance therapy for childhood neoplasms, most commonly acute lymphocytic leukemia. It is characterized by severe lower extremity pain and by osteoporosis particularly involving the lower extremities and thick dense provisional zones of calcification and growth arrest lines ...
A M, Schwartz, J C, Leonidas
openaire +2 more sources
Methotrexate osteopathy is an uncommon complication of long-term oral maintenance therapy for childhood neoplasms, most commonly acute lymphocytic leukemia. It is characterized by severe lower extremity pain and by osteoporosis particularly involving the lower extremities and thick dense provisional zones of calcification and growth arrest lines ...
A M, Schwartz, J C, Leonidas
openaire +2 more sources
Pharmacogenetics of methotrexate
Pharmacogenomics, 2004Methotrexate (MTX) has proven efficient in the treatment of a number of malignancies, as well as non-malignant disorders characterized by a rapid cellular growth. Yet some patients might develop resistance, while others could have toxic side effects. MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the ...
Maja, Krajinovic, Albert, Moghrabi
openaire +2 more sources