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The pharmacology of methotrexate
Expert Opinion on Pharmacotherapy, 2001Ectopic pregnancy (EP) is a major cause of maternal morbidity and mortality. The treatment of this condition is primarily surgical, but medical management in selected cases is safe, effective, cost-effective and eliminates the morbidity of surgery.
K, Barnhart, C, Coutifaris, M, Esposito
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The pharmacology of methotrexate
Journal of the American Academy of Dermatology, 1991Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population.
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Methotrexate for the neurologist
Practical NeurologyThe use of methotrexate in clinical practice has expanded significantly in recent years, as an effective chemotherapeutic agent as well as disease-modifying treatment for conditions such as rheumatoid arthritis, psoriasis and Crohn’s disease. It is also used as a steroid-sparing agent for a range of inflammatory diseases of the central and peripheral ...
Aaron Jesuthasan +6 more
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Expert Review of Clinical Pharmacology
Methotrexate polyglutamates (MTXPGs) are intracellular metabolites of methotrexate (MTX) that play a critical role in the drug's activity, influencing both its efficacy and toxicity. As the exact implications of MTXPGs in these processes remain a subject of debate, a comprehensive review of MTXPGs could provide valuable insights for clinicians and ...
Zhilin, Yang +4 more
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Methotrexate polyglutamates (MTXPGs) are intracellular metabolites of methotrexate (MTX) that play a critical role in the drug's activity, influencing both its efficacy and toxicity. As the exact implications of MTXPGs in these processes remain a subject of debate, a comprehensive review of MTXPGs could provide valuable insights for clinicians and ...
Zhilin, Yang +4 more
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JAMA: The Journal of the American Medical Association, 1973
The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
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The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
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Side effects of methotrexate therapy for rheumatoid arthritis: A systematic review.
European journal of medicinal chemistry, 2018Wanying Wang, Hua Zhou, Liang Liu
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Molecular mechanism of action and pharmacokinetic properties of methotrexate
Molecular Biology Reports, 2020V. Maksimovic +7 more
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