Results 1 to 10 of about 743 (145)

Methuosis Inducer SGI‐1027 Cooperates with Everolimus to Promote Apoptosis and Pyroptosis by Triggering Lysosomal Membrane Permeability in Renal Cancer [PDF]

Advanced Science
The mTOR inhibitor everolimus has been approved as a sequential or second‐line therapy for renal cell carcinoma (RCC). However, the development of drug resistance limits its clinical applications.
Yu Luo, Bing Guan, Xiaoqi Deng, Peide Bai, Haichao Huang, Chaohao Miao, Anran Sun, Zhipeng Li, Dianqiang Yang, Xuegang Wang, Zhiqiang Shao, Yulong Wu, Jinchun Xing, Bin Chen, Tao Wang   +14 more
doaj   +4 more sources

From Pinocytosis to Methuosis—Fluid Consumption as a Risk Factor for Cell Death [PDF]

Frontiers in Cell and Developmental Biology, 2021
The volumes of a cell [cell volume (CV)] and its organelles are adjusted by osmoregulatory processes. During pinocytosis, extracellular fluid volume equivalent to its CV is incorporated within an hour and membrane area equivalent to the cell’s surface ...
Markus Ritter, Markus Ritter, Markus Ritter, Markus Ritter, Markus Ritter, Nikolaus Bresgen, Hubert H. Kerschbaum   +6 more
doaj   +4 more sources

Cytoskeleton disruption and plasma membrane damage determine methuosis of normal and malignant cells [PDF]

Cell & Bioscience
Background Methuosis represents a novel cell death modality characterized by catastrophic cytoplasmic vacuolization in normal and malignant cells. However, the critical role and the underlying mechanism of cytoskeleton and plasma membrane damage in ...
Bin Dong, Jing Xiao, Junqi Wang, Xinhao Song, Hui Ji, Jiurong Peng, Xinru Weng, Dawei Guo, Shanxiang Jiang, Xiuge Gao   +9 more
doaj   +6 more sources

PI3K/mTOR Inhibitor Induces Context-Dependent Apoptosis and Methuosis in Cancer Cells [PDF]

Pharmaceuticals
Background/Objectives: Targeting the PI3K/mTOR pathway is a promising strategy in cancer therapy, but its efficacy is often limited by apoptosis resistance.
Xiaoyuan Hua, Panpan Chen, Wanjing Zeng, Yuqiao Han, Yanzhi Guo, Yanmei Chen, Chuchu Li, Yijie Du, Mingliang Ma, Suzhen Dong   +9 more
doaj   +3 more sources

Ionizing radiation results in a mixture of cellular outcomes including mitotic catastrophe, senescence, methuosis, and iron-dependent cell death [PDF]

Cell Death and Disease, 2020
Radiotherapy is commonly used as a cytotoxic treatment of a wide variety of tumors. Interestingly, few case reports underlined its potential to induce immune-mediated abscopal effects, resulting in regression of metastases, distant from the irradiated ...
Sandy Adjemian, Teodora Oltean, Sofie Martens, Bartosz Wiernicki, Vera Goossens, Tom Vanden Berghe, Benjamin Cappe, Maria Ladik, Franck B. Riquet, Liesbeth Heyndrickx, Jolien Bridelance, Marnik Vuylsteke, Katrien Vandecasteele, Peter Vandenabeele   +13 more
doaj   +4 more sources

Tubeimoside-2 Triggers Methuosis in Hepatocarcinoma Cells through the MKK4–p38α Axis [PDF]

Pharmaceutics, 2023
Liver cancer, consisting mainly of hepatocellular carcinoma, is the third leading cause of cancer-related mortality worldwide. Despite advances in targeted therapies, these approaches remain insufficient in meeting the pressing clinical demands. Here, we
Yichao Gan, Chen Wang, Yunyun Chen, Linxin Hua, Hui Fang, Shu Li, Shoujie Chai, Yang Xu, Jiawei Zhang, Ying Gu   +9 more
doaj   +4 more sources

Methuosis, Alkaliptosis, and Oxeiptosis and Their Significance in Anticancer Therapy [PDF]

Cells
Understanding morphological, biochemical, and functional aspects of cell death is essential for targeting new cancer therapies. Even though many different mechanisms of cell death are identified, it is crucial to highlight the role of new and lesser ...
Elżbieta Bartoszewska, Kamila Florek, Karol Zagórski, Martyna Gachowska, Anna Wietrzyk, Agata Hutny, Agnieszka Nowakowska-Toporowska, Julita Kulbacka   +7 more
doaj   +4 more sources

Methuosis key gene ARF6 as a diagnostic, prognostic and immunotherapeutic marker for prostate cancer: based on a comprehensive pan-cancer multi-omics analysis [PDF]

Discover Oncology
Background Prostate cancer (PCa) is a leading cause of cancer-related mortality among men worldwide. Despite progress in the understanding of tumor biology, the prognosis for advanced prostate cancer remains poor, necessitating the identification of ...
Yongjin Yang, Liangliang Qing, Chengyu You, Qingchao Li, Wenbo Xu, Zhilong Dong   +5 more
doaj   +4 more sources

Smart Nanoparticles Disrupting Energy Supply through Triple Mechanisms to Kill Tumors via Dual Disruption of Mitochondria and Lysosomes [PDF]

Advanced Science
Targeting mitochondrial disruption as a strategy for inhibiting cancer cell proliferation presents a promising therapeutic approach. However, the process of mitophagy plays a protective role in cancer cells by aiding in damage repair, regulating energy ...
Xiao Xu, Qiqing Huang, Yang Liu, Jinzhuo Liu, Deyi Yang, Yanni Song, Xin Han   +6 more
doaj   +3 more sources

Repurposing methuosis-inducing anticancer drugs for anthelmintic therapy. [PDF]

PLoS Pathogens
Drug-resistant parasitic nematodes pose a grave threat to plants, animals, and humans. An innovative paradigm for treating parasitic nematodes is emphasized in this opinion.
Satish Kumar Rajasekharan, Vinothkannan Ravichandran, Bharath Reddy Boya, Anirudh Jayachandran, Jintae Lee   +4 more
doaj   +3 more sources