Results 91 to 100 of about 793 (162)

Paradigm Shift in Gastric Cancer Prevention: Harnessing the Potential of Aristolochia olivieri Extract [PDF]

, 2023
Gastric cancer, particularly adenocarcinoma, is a significant global health concern. Environmental risk factors, such as Helicobacter pylori infection and diet, play a role in its development. This study aimed to characterize the chemical composition and
Abdullah F. O., Battistelli M., Burattini S., Canale M., Caprioli G., D'Agostino F., Faenza I., Mari M., Micucci M., Piatti D., Retini M., Roncarati D., Sagratini G., Salucci S., Stella Bartoletti A., Versari I.   +15 more
core   +1 more source

Integrating Multi‐Omics Data Using Machine Learning to Explore New Therapeutic Targets for Acute Kidney Injury

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Renal ischemia–reperfusion (I/R) injury is an unavoidable complication associated with renal transplantation, and currently, there are no targeted therapeutic interventions. The objective of this study was to explore the molecular mechanisms that contribute to I/R‐induced acute kidney injury (I/R‐AKI) and to discover potential targets for ...
Qiming Gong, Yakun Wang, Fahui Liu, Tingting Zhou, Mengqin Tu, Junle Li, Wei Huang, Xu Lin, Wenjuan Sun   +8 more
wiley   +1 more source

Novel selective inhibitors of macropinocytosis-dependent growth in pancreatic ductal carcinoma [PDF]

Macropinocytosis is a cellular process that enables cells to engulf extracellular material, such as nutrients, growth factors, and even whole cells. It is involved in several physiological functions as well as pathological conditions.
Andronache, Adrian, Brambillasca, Silvia, Cera, Maria Rosaria, Dey, Sumit Kumar, Fagá, Giovanni, Fancelli, Daniele, Frittoli, Emanuela, Mercurio, Ciro, Pasi, Maurizio, Robusto, Michela, Scita, Giorgio, Varasi, Mario   +11 more
core   +1 more source

Nanomedicine Approaches for Autophagy Modulation in Cancer Therapy

Small Science, Volume 5, Issue 6, June 2025.
Autophagy modulation holds promise for enhancing cancer treatment, yet clinical translation remains challenging. This review explores nanomedicine‐based strategies to improve autophagy‐targeting drugs, highlighting their synergy with chemotherapy, immunotherapy, phototherapy, and gene therapy. It also discusses nanoparticle design and clinical progress,
Sohaib Mahri, Rodolfo Villa, Ya‐Ping Shiau, Menghuan Tang, Kelsey Jane Racacho, Qiufang Zong, Saiful Islam Chowdhury, Tan Hua, Felipe Godinez, Andrew Birkeland, Tzu‐Yin Lin, Yuanpei Li   +11 more
wiley   +1 more source

Studies on autophagy and apoptosis of fibrosarcoma HT-1080 cells mediated by chalcone with indole moiety [PDF]

This study demonstrated the anticancer efficacy of chalcones with indole moiety (MIPP, MOMIPP) in fibrosarcoma cells for the first time. The results showed that MIPP and MOMIPP reduced the viability of HT-1080 cells in a concentration-dependent manner ...
Barczyk-Woźnicka, Olga, Handzlik, Jadwiga, Honkisz-Orzechowska, Ewelina, Kaleta, Maria, Kieć-Kononowicz, Katarzyna   +4 more
core   +2 more sources

Macropinocytosis in Different Cell Types: Similarities and Differences [PDF]

, 2020
Macropinocytosis is a unique pathway of endocytosis characterised by the nonspecific internalisation of large amounts of extracellular fluid, solutes and membrane in large endocytic vesicles known as macropinosomes.
Gleeson, PA, Lin, XP, Mintern, JD
core   +1 more source

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

Molecular Oncology, 2015
AS1411 is a G‐rich quadruplex‐forming oligodeoxynucleotide that binds specifically to nucleolin, a protein found on the surface and in the cytoplasm of most malignant cells but absent from the surface/cytoplasm of most normal cells.
E. Merit Reyes-Reyes, Francesca R. Šalipur, Mitra Shams, Matthew K. Forsthoefel, Paula J. Bates   +4 more
doaj   +1 more source

Beyond biomarkers: Exploring the diverse potential of a novel phosphoprotein in lung cancer management

Journal of Cellular and Molecular Medicine, Volume 28, Issue 18, September 2024.
Abstract In addressing the challenges of lung cancer, attention has increasingly turned to molecular diagnostics and targeted therapies, with nucleolin (NCL) assuming a pivotal role, especially in non‐small cell lung cancer. The aberrant activity and cellular distribution of NCL act as crucial biomarkers for early detection and treatment monitoring ...
Amirabbas Rostami, Ehsan Ranjbar, Somayeh Amiri, Fatemeh Ezzatifar   +3 more
wiley   +1 more source

Massive entry of BK Polyomavirus induces transient cytoplasmic vacuolization of human renal proximal tubule epithelial cells [PDF]

BK polyomavirus (BKPyV) is a ubiquitous human virus that establishes a persistent infection in renal tubular epithelial cells and mainly causes disease in kidney transplant recipients.
Henriksen, Stian, Lorentzen, Elias Myrvoll, Rinaldo, Christine Hanssen   +2 more
core   +1 more source

Investigating the mechanism of novel anticancer agent, AS1411 : does metabolism to guanine play a role? [PDF]

, 2017
AS1411 is an oligonucleotide that has shown promising results in lab experiments and clinical trials as an anti-cancer drug, Likewise, treatments with guanine based purine compounds (GBPCs) have demonstrated similar anti-proliferative effects in vitro ...
Howard, Parker T
core   +1 more source