Results 141 to 150 of about 793 (162)

Importance of the a,ß-Unsaturated Ketone in Methuosis-Inducing Compounds

, 2015
Jennifer M. Offenbacher
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Identification of Renal Ischemia-Reperfusion Injury Subtypes and Predictive Model for Graft Loss after Kidney Transplantation Based on Programmed Cell Death-Related Genes. [PDF]

Kidney Dis (Basel)
Ji J, Ma Y, Liu X, Zhou Q, Zheng X, Chen Y, Li Z, Yang L.   +7 more
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Exploring paraptosis as a therapeutic approach in cancer treatment. [PDF]

J Biomed Sci
Chang LC, Chiang SK, Chen SE, Hung MC.
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Making bubbles: Targeting VPS41 induces vacuolization and methuosis

Cell Chemical Biology, 2023
In this issue of Cell Chemical Biology, Liu et al. describe the natural product DMBP as the first tool compound for VPS41. Treatment with DMBP induced vacuolization and methuosis and inhibited autophagic flux in lung and pancreatic cancer cell lines, validating VPS41 as a potential therapeutic target.
Nienke Julia, Dekker, Luca, Laraia
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Targeting VPS41 induces methuosis and inhibits autophagy in cancer cells

Cell Chemical Biology, 2023
The homotypic fusion and vacuole protein sorting (HOPS) complex mediates membrane trafficking involved in endocytosis, autophagy, lysosome biogenesis, and phagocytosis. Defects in HOPS subunits are associated with various forms of cancer, but their potential as drug targets has rarely been examined.
Yue, Liu, Yong, Sun, Yuliang, Xu, Ting, Dong, Lilin, Qian, Hongbo, Zheng, Yun, Gao, Zhaojun, Chu, Xiaojie, Fu, Hanrui, Zhang, Feng, Xie, Chunyang, Zhang, Yajie, Tang, Hongxiang, Lou   +13 more
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Maduramicin induces cardiotoxicity via Rac1 signaling‐independent methuosis in H9c2 cells

Journal of Applied Toxicology, 2021
AbstractMaduramicin frequently induces severe cardiotoxicity in target and nontarget animals in clinic. Apoptotic and non‐apoptotic cell death mediate its cardiotoxicity; however, the underlying non‐apoptotic cell death induced by maduramicin remains unclear.
Xiuge Gao, Chunlei Ji, Junqi Wang, Xinhao Song, Runan Zuo, Jingjing Zhang, Xiaorong Chen, Hui Ji, Peng Lin, Dawei Guo, Shanxiang Jiang   +10 more
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Maduramicin triggers methuosis-like cell death in primary chicken myocardial cells

Toxicology Letters, 2020
Maduramicin frequently induces severe cardiotoxicity in broiler chickens as well as in humans who consume maduramicin accidentally. Apoptosis and non-apoptotic cell death occur concurrently in the process of maduramicin-induced cardiotoxicity; however, the underlying mechanism of non-apoptotic cell death is largely unknown.
Xiuge Gao, Xiangchun Ruan, Hui Ji, Lin Peng, Yawei Qiu, Dan Yang, Xinhao Song, Chunlei Ji, Dawei Guo, Shanxiang Jiang   +9 more
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Spiropachysine A suppresses hepatocellular carcinoma proliferation by inducing methuosis in vitro and in vivo

Phytomedicine, 2022
Spiropachysine A is the extracted compound of traditional Chinese ethnic medicine Pachysandra axillaries Franch. var. styiosa (Dunn) M. Cheng. Spiropachysine A is the primary active steroidal alkaloids (SAs) widely used to facilitate blood circulation and relieve pain and inflammation.
Yuan Fang, Ting Zhong, Lishou Yang, Fang Luo, Qing Li, Daoping Wang, Qi‐Ji Li, Yanhua Fan, Xiaosheng Yang   +8 more
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Isobavachalcone reveals novel characteristics of methuosis-like cell death in leukemia cells

Chemico-Biological Interactions, 2019
Non-apoptotic cell-death induction is a potential strategy for cancer treatment. Cytoplasmic vacuolation-associated cell death represents a novel type of non-apoptotic cell-death. Here, we showed that isobavachalcone (IBC), a naturally occurring chalcone compound, selectively induced cell death with massive cytoplasmic vacuolation in some leukemic ...
Li, Yang, Lili, Song, Shan, Zhao, Chunmin, Ma, Depei, Wu, Ying-Li, Wu   +5 more
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Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity

Small, 2021
AbstractDiscovering new drugs and improving action mechanisms is a promising strategy to overcome chemotherapy ineffectiveness caused by cancer cell apoptosis resistance. Natural products (like cyclic lipopeptides, CLPs) are potential sources of nonapoptotic cell death inducers and can form diverse supramolecular structures, closely relating to their ...
Jiao Lu, Wei Tao Huang, Kexuan Zhou, Xiaoli Zhao, Shu‐Qing Yang, Liqiu Xia, Xuezhi Ding   +6 more
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