Results 151 to 160 of about 793 (162)

V-ATPase V0 subunit activation mediates maduramicin-induced methuosis through blocking endolysosomal trafficking in vitro and in vivo

Food and Chemical Toxicology, 2023
Methuosis, a novel cell death phenotype, is characterized by accumulation of cytoplasmic vacuolization upon external stimulus. Methuosis plays a critical role in maduramicin-induced cardiotoxicity despite the underlying mechanism is largely unknown. Herein, we aimed to investigate the origin and intracellular trafficking of cytoplasmic vacuoles, as ...
Yuling, Zheng, Jing, Xiao, Junqi, Wang, Bin, Dong, Dawei, Guo, Hui, Ji, Haifeng, Sun, Lin, Peng, Shanxiang, Jiang, Xiuge, Gao   +9 more
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Discovery of Pyrimidinediamine Derivatives as Potent Methuosis Inducers for the Treatment of Triple-Negative Breast Cancer

Journal of Medicinal Chemistry, 2023
Triple-negative breast cancer (TNBC) is a leading malignancy among women that currently lack effective targeted therapeutic agents, and the limitations of treatment have prompted the emergence of new strategies. Methuosis is a novel vacuole-presenting cell death modality that promotes tumor cell death.
Jia He, Luzhen Wang, DaZhao Mi, Tian Guan, Wenjing Liu, Peng He, Haijun Gu, Yuzhan Li, Yangrui Peng, Ai-Qun Jia, Ceshi Chen, Yihua Chen   +11 more
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Oral delivery of MOMIPP lipid nanoparticles for methuosis-induced cancer chemotherapy

Nanoscale
MOMIPP-SEDDS increased the relative bioavailability by 19.98-fold and achieved favorable tumor inhibition. Clear evidence of methuosis in the tumor tissue following MOMIPP-SEDDS treatment was revealed by TEM imaging.
Zeyuan Mao, Guihong Chai
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[Methuosis: a novel type of cell death].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2015
Cell death is a major physiological or pathological phenomenon in life activities. The classic forms of cell death include apoptosis, necrosis, and autophagy. Recently, a novel type of cell death has been observed and termed as methuosis, in which excessive stimuli can induce cytoplasmic uptake and accumulation of small bubbles that gradually merge ...
Hongbing, Cai, Jinkun, Liu, Qin, Fan, Xin, Li   +3 more
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Discovery and Identification of Small Molecules as Methuosis Inducers with in Vivo Antitumor Activities

Journal of Medicinal Chemistry, 2018
Methuosis is a novel nonapoptotic mode of cell death characterized by vacuole accumulation in the cytoplasm. In this article, we describe a series of azaindole-based compounds that cause vacuolization in MDA-MB-231 cells. The most potent vacuole inducer, compound 13 (compound 13), displayed differential cytotoxicities against a broad panel of cancer ...
Wei Huang, Xihuan Sun, Yunzhan Li, Zhixiang He, Li Li, Zhou Deng, Xiaoxing Huang, Shang Han, Ting Zhang, Jiaji Zhong, Zheng Wang, Qingyan Xu, Jianming Zhang, Xianming Deng   +13 more
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A novel methuosis inducer DZ-514 possesses antitumor activity via activation of ROS-MKK4-p38 axis in triple negative breast cancer

Cancer Letters, 2023
Triple-negative breast cancer (TNBC) is one of the most malignant tumors with poor prognosis. Methuosis is a new type of nonapoptotic cell death characterized by the accumulation of cytoplasmic vacuoles. In this study, we synthesized and screened a series of N-phenyl-4-pyrimidinediamine derivatives in TNBC cells, finding that DZ-514 was the best ...
Luzhen Wang, Dazhao Mi, Jinhui Hu, Wenjing Liu, Yi Zhang, Chunyan Wang, Yihua Chen, Ceshi Chen   +7 more
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Approaches to selective and potent inhibition of glioblastoma by vanadyl complexes: Inducing mitotic catastrophe and methuosis

Journal of Inorganic Biochemistry
Drug resistance has been a major problem for cancer chemotherapy, especially for glioblastoma multiforme that is aggressive, heterogeneous and recurrent with
Sha Xu, Huixue Liu, Xin Li, Jingyan Zhao, Jiayu Wang, Debbie C. Crans, Xiaoda Yang   +6 more
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Methuosis - A promising lead for the treatment of oral squamous cell carcinoma

Journal of Stomatology, Oral and Maxillofacial Surgery, 2023
Reshma Poothakulath, Krishnan, Pratibha, Ramani, Deepak, Pandiar   +2 more
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METHUOSIS AS AN EFFECTIVE ROUTE OF CELL DEATH IN ANTINEOPLASTIC THERAPY TARGETING SOLID TUMORS: A SCOPING REVIEW

A morte celular é essencial à manutenção do funcionamento orgânico. A metuose é um tipo de morte celular do tipo não apoptótica, induzindo macropinocitose. Atualmente, vem sendo estudada sobre seus efeitos no câncer. Com base nisso, busca-se analisar os avanços no tratamento antineoplásico baseado em indução da metuose, identificando as neoplasias ...
de Sousa, Jorge Rodrigues, LUAN DAHER FERNANDES, Gondim, Letícia Cavalcante, Castelo, Elinton Nascimento   +3 more
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[Mechanism of Platycarya strobilacea Sieb. et Zucc extract-induced methuosis in human nasopharyngeal carcinoma CNE1 and CNE2 cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2018
To study the effect of Platycarya strobilacea Sieb. et Zucc (PSZ) extract on methuosis of human nasopharyngeal carcinoma CNE1 and CNE2 cells and explore the underlying mechanism.CNE1 and CNE2 cells were treated with 1 mg/mL PSZ extract and the expressions of Rac1 mRNA and Rac1 protein were detected using RT-qPCR and Western blotting, respectively ...
Jun-Yu, Zhu, Wei, Tu, Chao, Zeng, Heng-Xu, Mao, Qing-Feng, DU, Hong-Bing, Cai   +5 more
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