Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation [PDF]
Frontiers in PharmacologyBackgroundTanshinlactone is a compound derived from the herb Salvia miltiorrhiza. Breast cancer is the most prevalent malignancy among women globally.
Wanjun Lin +8 more
doaj +5 more sources
A chalcone-related small molecule that induces methuosis, a novel form of non-apoptotic cell death, in glioblastoma cells [PDF]
Molecular Cancer, 2011 Background Methuosis is a unique form of non-apoptotic cell death triggered by alterations in the trafficking of clathrin-independent endosomes, ultimately leading to extreme vacuolization and rupture of the cell.
Bhanot Haymanti +3 more
doaj +9 more sources
CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism [PDF]
Cancers, 2018 Cholangiocarcinoma is a disease with a poor prognosis and increasing incidence and hence there is a pressing unmet clinical need for new adjuvant treatments. Protein kinase CK2 (previously casein kinase II) is a ubiquitously expressed protein kinase that
Afford, Simon +9 more
core +8 more sources
The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma [PDF]
BMC Cancer, 2019 Background Synthetic indolyl- pyridinyl- propenones (IPPs) induce methuosis, a form of non-apoptotic cell death, in glioblastoma and other cancer cell lines.
Zehui Li +7 more
doaj +4 more sources
Methuosis caused by dysregulated macropinocytosis, a promising tumor therapeutic strategy
Pharmacological ResearchNonapoptotic programmed cell death (PCD) has been recognized as potential alternative target for increasing chemosensitivity and augmenting antitumor efficacy.
Xinpei Ji, Mingyan Huang, Qiuyan Liu
doaj +3 more sources
Ecotoxicology and Environmental SafetyNanoplastic pollution has emerged as a significant environmental concern, with increasing evidence suggesting that these nanoparticles can disrupt the blood-brain barrier (BBB) and accumulate in the brain, ultimately leading to neurological impairment ...
Suhan Yin +6 more
doaj +3 more sources
Hypoxia response in glioblastoma cells: effect of trehalose on macropinocytosis, autophagy and cell survival [PDF]
Biochemistry and Biophysics ReportsIn glioblastoma multiforme, the most malignant brain tumor in adults, the hypoxic milieu is believed to contribute to tumor aggressiveness and resistance to therapy.
Barbara Del Bello +2 more
doaj +5 more sources
Nutlin-3a induces KRAS mutant/p53 wild type lung cancer specific methuosis-like cell death that is dependent on GFPT2 [PDF]
Journal of Experimental & Clinical Cancer Research, 2023 Background Oncogenic KRAS mutation, the most frequent mutation in non-small cell lung cancer (NSCLC), is an aggressiveness risk factor and leads to the metabolic reprogramming of cancer cells by promoting glucose, glutamine, and fatty acid absorption and
Dasom Kim +10 more
doaj +4 more sources
Assessments of iodoindoles and abamectin as inducers of methuosis in pinewood nematode, Bursaphelenchus xylophilus [PDF]
Scientific Reports, 2017 Bursaphelenchus xylophilus is a quarantined migratory endoparasite known to cause severe economic losses in pine forest ecosystems. The study presents the nematicidal effects of halogenated indoles on B. xylophilus and their action mechanisms.
Satish Kumar Rajasekharan +3 more
doaj +5 more sources
The Dual Role of Macropinocytosis in Cancers: Promoting Growth and Inducing Methuosis to Participate in Anticancer Therapies as Targets [PDF]
Frontiers in Oncology, 2021 Macropinocytosis is an important mechanism of internalizing extracellular materials and dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells.
Shaojuan Song +4 more
doaj +4 more sources