Ethanol Extract of the Infructescence of Platycarya strobilacea Sieb. et Zucc. Induces Methuosis of Human Nasopharyngeal Carcinoma Cells [PDF]
Evidence-Based Complementary and Alternative Medicine, Volume 2020, Issue 1, 2020., 2020 The infructescence of Platycarya strobilacea Sieb. et Zucc. (PS) has been used in the treatment of rhinitis and sinusitis in clinical practice. Our preliminary study showed that an ethanol extract of the infructescence of PS (EPS) had significant antinasopharyngeal carcinoma (NPC) effects in vitro.
Jinkun Liu, Min Ying, Bin Wu, Chaomei Fu
wiley +4 more sources
The Mechanisms of Regulated Cell Death: Structural and Functional Proteomic Pathways Induced or Inhibited by a Specific Protein—A Narrative Review [PDF]
ProteomesBillions of cells die in us every hour, and our tissues do not shrink because there is a natural regulation where Cell Death (CD) is balanced with cell division.
Diego Fernández-Lázaro +2 more
doaj +6 more sources
Methuosis Contributes to Jaspine-B-Induced Cell Death. [PDF]
Int J Mol Sci, 2022 Methuosis is a type of programmed cell death in which the cytoplasm is occupied by fluid-filled vacuoles that originate from macropinosomes (cytoplasmic vacuolation). A few molecules have been reported to behave as methuosis inducers in cancer cell lines.
Bielsa N +7 more
europepmc +8 more sources
Casein kinase 2 phosphorylates and induces the SALL2 tumor suppressor degradation in colon cancer cells [PDF]
Cell Death and DiseaseSpalt-like proteins are Zinc finger transcription factors from Caenorhabditis elegans to vertebrates, with critical roles in development. In vertebrates, four paralogues have been identified (SALL1-4), and SALL2 is the family’s most dissimilar member ...
V. E. Hermosilla +16 more
doaj +4 more sources
Novel Metabolites from the Marine-Derived Fungus Peniophora sp. SCSIO41203 Show Promising In Vitro Antitumor Activity as Methuosis Inducers in PC-3 Cells [PDF]
Marine DrugsTwo new cytochalasin derivatives, peniotrinins A (1) and B (2), three new citrinin derivatives, peniotrinins C–E (4, 5, 7), and one new tetramic acid derivative, peniotrinin F (12), along with nine structurally related known compounds, were isolated from
Bin Yang +9 more
doaj +4 more sources
Progress in the discovery and development of small molecule methuosis inducers. [PDF]
RSC Med Chem, 2023 The discovery and development of small molecule methuosis inducers and their modes of action were summarized for the first time.
Ye T, Shan P, Zhang H.
europepmc +5 more sources
Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE [PDF]
ACS Omega, 2018 Methuosis is a form of nonapoptotic cell death characterized by the accumulation of macropinosome-derived vacuoles. Herein, we identify PIKFYVE, a class III phosphoinositide (PI) kinase, as the protein target responsible for the methuosis-inducing activity of indolyl-pyridinyl-propenones (3-(5-methoxy-2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1 ...
Hyelim Cho +6 more
doaj +4 more sources
Design, synthesis, and biological evaluation of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-Indole-2-Carbohydrazide derivatives: the methuosis inducer 12A as a Novel and selective anticancer agent [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2021 This study describes the synthesis and vacuole-inducing activity of 5-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-1H-indole-2-carbohydrazide derivatives, including five potent derivatives 12c, 12 g, 12i, 12n, and 12A that exhibit excellent vacuole-inducing ...
Jun Wu +9 more
doaj +2 more sources
Targeting protein kinase CK2 in the treatment of cholangiocarcinoma [PDF]
Exploration of Targeted Anti-tumor Therapy, 2021 Cholangiocarcinoma (CCA) is a disease with a very poor prognosis and limited treatment options. Although targeted therapies directed towards specific mutations found in CCA are becoming available and are showing great potential, many tumors do not carry ...
Padma-Sheela Jayaraman
doaj +3 more sources
The Role and Therapeutic Potential of Macropinocytosis in Cancer [PDF]
Frontiers in Pharmacology, 2022 Macropinocytosis, a unique endocytosis pathway characterized by nonspecific internalization, has a vital role in the uptake of extracellular substances and antigen presentation.
Zejing Qiu +41 more
doaj +2 more sources