CDK7 inhibition promotes glioblastoma cell death through convergent transcriptional and metabolic stress pathways. [PDF]
Clin Transl MedClinical and Translational Medicine, Volume 15, Issue 8, August 2025.
Freitag T +17 more
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Сell death and its significance in reproductive pathology [PDF]
Ukrainian Journal of Veterinary and Agricultural Sciences, 2021 Since the middle of the last century, scientists have been interested in the mechanisms of regulation of cell division, differentiation and aging of cells. The first objects of study were insects, helminths and other living organisms.
M. M. Zhelavskyi +2 more
doaj +3 more sources
Investigating ionizing radiation-induced changes in breast cancer cells using stimulated Raman scattering microscopy. [PDF]
J Biomed Opt, 2023 Significance Altered lipid metabolism of cancer cells has been implicated in increased radiation resistance. A better understanding of this phenomenon may lead to improved radiation treatment planning. Stimulated Raman scattering (SRS) microscopy enables
Allen CH +9 more
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Cytoplasmic Vacuolization: A Fascinating Morphological Alteration From Cellular Stress to Cell Death. [PDF]
Cancer SciThis review provides a thorough examination of contemporary studies on cytoplasmic vacuolization in mammalian cells, elucidating its etiology, origins, and molecular pathways. Additionally, it highlights the potential of CVACD as an innovative therapeutic strategy for cancer.
Wen X, Ma H.
europepmc +2 more sources
Types of Cell Death from a Molecular Perspective [PDF]
Biology, 2023 The former conventional belief was that cell death resulted from either apoptosis or necrosis; however, in recent years, different pathways through which a cell can undergo cell death have been discovered. Various types of cell death are distinguished by
Fatemeh Hajibabaie +2 more
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Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis [PDF]
Frontiers in Pharmacology, 2018 Macropinocytosis is a highly conserved endocytic process which characterizes the engulfment of extracellular fluid and its contents into cells via large, heterogeneous vacuoles known as macropinosomes.
Xianling Gong +10 more
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Macropinocytosis: Both a Target and a Tool for Cancer Therapy [PDF]
BiomoleculesMacropinocytosis is a non-selective, clathrin-independent endocytic process that facilitates bulk internalization of extracellular fluid and its dissolved components (including proteins, lipids, and nucleotides) through plasma membrane remodeling and the
Manhan Zhao +5 more
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Potential Role of CD99 Signaling Pathway in Schwann Cell Dysfunction in Diabetic Foot Ulcers Based on Single-Cell Transcriptome Analysis. [PDF]
J Diabetes ResBackground: Schwann cell (SC) dysfunction contributes to the delayed healing of diabetic foot ulcers (DFUs). However, the underlying molecular mechanism regarding the unregulated SC function is poorly understood. Thus, we examined the single‐cell transcriptome data from different DFU states focusing on SC characteristics.
Zhou Y, Zhou Y, Chen H, Zhang L, Bi S.
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Diversity and complexity of cell death: a historical review [PDF]
Experimental and Molecular Medicine, 2023 Death is the inevitable fate of all living organisms, whether at the individual or cellular level. For a long time, cell death was believed to be an undesirable but unavoidable final outcome of nonfunctioning cells, as inflammation was inevitably ...
Wonyoung Park +7 more
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Inhibition of platin-induced BCL2 increase overcomes chemoresistance in squamous cell carcinoma of the head and neck through resensitization to cell death [PDF]
Translational OncologyThe clinical outcome of head and neck squamous cell carcinoma (HNSCC) remains poor with high recurrence rates, in part due to resistance to concurrent platinum-based chemotherapy.
Anne-Sophie Becker +6 more
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