Comprehensive landscape of cell death mechanisms: from molecular cross-talk to therapeutic innovation in oncology [PDF]
Frontiers in Cell and Developmental BiologyCell death, or programmed cellular termination, represents a fundamental biological phenomenon crucial for maintaining organismal homeostasis. Traditionally conceptualized as a passive terminal state associated with inflammatory responses and elimination
Ke Qi +5 more
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Establishing safe high hydrostatic pressure devitalization thresholds for autologous head and neck cancer vaccination and reconstruction [PDF]
Cell Death Discovery, 2023 High hydrostatic pressure specifically devitalizes cells and tissues without major changes in their molecular structure. Hence, high hydrostatic pressure may enhance the development of whole-cell anti-tumor vaccines, representing tumor heterogeneity and ...
Claudia Maletzki +13 more
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Anti-c-MET Fab-Grb2-Gab1 Fusion Protein-Mediated Interference of c-MET Signaling Pathway Induces Methuosis in Tumor Cells. [PDF]
Int J Mol Sci, 2022 Dou X +9 more
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Lipid accumulation in human breast cancer cells injured by iron depletors [PDF]
Journal of Experimental & Clinical Cancer Research, 2018 Background Current insights into the effects of iron deficiency in tumour cells are not commensurate with the importance of iron in cell metabolism. Studies have predominantly focused on the effects of oxygen or glucose scarcity in tumour cells, while ...
Maida De Bortoli +9 more
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The American Journal of Pathology, 2014 Apoptosis is the most widely recognized form of physiological programmed cell death. During the past three decades, various nonapoptotic forms of cell death have gained increasing attention, largely because of their potential importance in pathological processes, toxicology, and cancer therapy.
William A. Maltese, Jean H. Overmeyer
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Correction: Lertsuwan et al. CX-4945 Induces Methuosis in Cholangiocarcinoma Cell Lines by a CK2-Independent Mechanism. <i>Cancers</i> 2018, <i>10</i>, 283. [PDF]
Cancers (Basel), 2022 Lertsuwan J +9 more
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CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells [PDF]
Cell Death & Disease, 2019 AbstractProtein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that phosphorylates a large number of substrates, resulting in increased cell proliferation and survival. A known target of CK2 is Akt, a player in the PI3K/Akt/mTORC1 signaling pathway, which is aberrantly activated in 32% of colorectal cancer (CRC) patients.
Eduardo Silva-Pavez +12 more
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Identification and analysis of diverse programmed cell death patterns in idiopathic pulmonary fibrosis using microarray-based transcriptome profiling and single-nucleus RNA sequencing. [PDF]
Front Med (Lausanne)BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, progressive pulmonary disorder marked by the gradual substitution of lung tissue with fibrotic tissue, resulting in respiratory failure.
Sun J, Zeng Y.
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Synthesis and Biological Evaluation of Indolyl-Pyridinyl-Propenones Having Either Methuosis or Microtubule Disruption Activity [PDF]
Journal of Medicinal Chemistry, 2015 Methuosis is a form of nonapoptotic cell death characterized by an accumulation of macropinosome-derived vacuoles with eventual loss of membrane integrity. Small molecules inducing methuosis could offer significant advantages compared to more traditional anticancer drug therapies that typically rely on apoptosis. Herein we further define the effects of
Christopher Trabbic +7 more
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Epimedokoreanin C, a prenylated flavonoid isolated from Epimedium koreanum, induces non-apoptotic cell death with the characteristics of methuosis in lung cancer cells. [PDF]
Am J Cancer Res, 2021 Liu X +6 more
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