Results 51 to 60 of about 793 (162)

Assays and ligands for underexplored membrane proteins with potential as future drug targets [PDF]

, 2023
In this study, pharmacological assays were established and employed to identify and characterize compounds regarding their potential as tool compounds, lead structures, and drug candidates for three underexplored potential drug targets. MRGPRX4 is
Gedschold, Robin Simon
core   +1 more source

CD99 triggering induces methuosis of Ewing sarcoma cells through IGF-1R/RAS/Rac1 signaling

Oncotarget, 2016
CD99 is a cell surface molecule that has emerged as a novel target for Ewing sarcoma (EWS), an aggressive pediatric bone cancer. This report provides the first evidence of methuosis in EWS, a non-apoptotic form of cell death induced by an antibody directed against the CD99 molecule. Upon mAb triggering, CD99 induces an IGF-1R/RAS/Rac1 complex, which is
Maria Cristina Manara, Mario Terracciano, Caterina Mancarella, Marika Sciandra, Clara Guerzoni, Michela Pasello, Andrea Grilli, Nicoletta Zini, Piero Picci, Mario P. Colombo, Andrea Morrione, Katia Scotlandi   +11 more
  +7 more sources

Discovery of Potent and Selective Phosphatidylinositol 3-Phosphate 5-Kinase (PIKfyve) Inhibitors as Methuosis Inducers

Journal of Medicinal Chemistry, 2023
Cytoplasmic vacuolation-associated cell death, known as methuosis, offers a promising nonapoptotic approach for cancer treatment. In this study, we outline the synthesis and evaluation of potent methuosis-inducing compounds. These compounds selectively induce cell death, characterized by extensive cytoplasmic vacuolation in HeLa and MDA-MB-231 cells ...
Yong Chen, Shuai Liu, Yuhan Wei, Haoche Wei, Yuan Xue, Baojian Xiong, Minghai Tang, Tao Yang, Zhuang Yang, Haoyu Ye, Jianhong Yang, Lijuan Chen   +11 more
openalex   +3 more sources

An Ultrastructural Perspective on Cell Death [PDF]

, 2022
In the field of cell death, there is still a wide gap between the molecular models and their ultrastructural phenotypes. Because only very few published works included electron microscopy (EM) images, many ultrastructural features have not yet been ...
Abu-Asab, Mones, Najdawi, Zaid
core   +2 more sources

Target-Based Anticancer Indole Derivatives for the Development of Anti-Glioblastoma Agents [PDF]

, 2023
Glioblastoma (GBM) is the most aggressive and frequent primary brain tumor, with a poor prognosis and the highest mortality rate. Currently, GBM therapy consists of surgical resection of the tumor, radiotherapy, and adjuvant chemotherapy with ...
Baglini, Emma, Barresi, Elisabetta, Da Settimo, Federico, Poggetti, Valeria, Salerno, Silvia, Taliani, Sabrina   +5 more
core   +1 more source

Correction to Indolyl-Pyridinyl-Propenone-Induced Methuosis through the Inhibition of PIKFYVE [PDF]

ACS Omega, 2018
Hyelim Cho, Erin Geno, Maude Patoor, A. M. REID, Richard I. McDonald, Marc Hild, Jeremy L. Jenkins   +6 more
openalex   +2 more sources

Synthesis and Evaluation of Indole-Based Chalcones as Inducers of Methuosis, a Novel Type of Nonapoptotic Cell Death [PDF]

Journal of Medicinal Chemistry, 2012
Methuosis is a novel caspase-independent form of cell death in which massive accumulation of vacuoles derived from macropinosomes ultimately causes cells to detach from the substratum and rupture. We recently described a chalcone-like compound, 3-(2-methyl-1H-indol-3-yl)-1-(4-pyridinyl)-2-propen-1-one (i.e., MIPP), which can induce methuosis in ...
Michael W. Robinson, Jean H. Overmeyer, Ashley Young, Paul Erhardt, William A. Maltese   +4 more
openalex   +4 more sources

Nematicidal effect of an Amaranthus hypochondriacus L. cystatin (AhCPI) on the root‐knot nematode Meloidogyne incognita (Kofoid and White) Chitwood

Annals of Applied Biology, Volume 183, Issue 3, Page 244-253, November 2023., 2023
Nematicidal effect of an Amaranthus hypochondriacus L. cystatin (AhCPI) on the root‐knot nematode Meloidogyne incognita. Abstract The root‐knot nematode Meloidogyne incognita is one of the most damaging plant parasitic nematodes in the world. In this study, the effect of cystatin from Amaranthus hypochondriacus (AhCPI) as a potential control agent for ...
María Magdalena Cervantes‐Juan, Jorge E. Ibarra, Víctor Olalde‐Portugal, María Karina Manzo‐Valencia, Marco Antonio Meraz Mercado, Silvia Valdés‐Rodríguez   +5 more
wiley   +1 more source

The Aptamer Functionalized Nanocomposite Used for Prostate Cancer Diagnosis and Therapy

Journal of Nanomaterials, Volume 2022, Issue 1, 2022., 2022
Prostate cancer is one of the major malignancies that threaten men’s health all over the world. Due to the lack of specific symptoms and signs in the early stage, as well as the limitations of existing detection methods, it is difficult to achieve early diagnosis for prostate cancer.
Xiaoqian Feng, Yinxing Zhu, Fujin Wang, Ting Guo, Xiaofeng Dou, Mei Lin, Weizhong Tian, Vidyadhar Singh   +7 more
wiley   +1 more source

Diverse roles of microbial indole compounds in eukaryotic systems

Biological Reviews, Volume 96, Issue 6, Page 2522-2545, December 2021., 2021
ABSTRACT Indole and its derivatives are widespread across different life forms, functioning as signalling molecules in prokaryotes and with more diverse roles in eukaryotes. A majority of indoles found in the environment are attributed to bacterial enzymes converting tryptophan into indole and its derivatives.
Prasun Kumar, Jin‐Hyung Lee, Jintae Lee   +2 more
wiley   +1 more source