Results 61 to 70 of about 793 (162)
Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization. [PDF]
, 2014 We have previously demonstrated that Stat3 regulates lysosomal-mediated programmed cell death (LM-PCD) during mouse mammary gland involution in vivo. However, the mechanism that controls the release of lysosomal cathepsins to initiate cell death in this ...
A Fontana +65 more
core +3 more sources
Cell Death Discovery, 2022 Double-hit lymphoma is one of the most aggressive and refractory lymphoma subtypes with recurrent genetic abnormalities of MYC and BCL-2 or BCL6 rearrangement, leading to a poor prognosis in the present clinical practice.
Liying Feng +9 more
doaj +1 more source
Role of CK2 inhibitor CX-4945 in anti-cancer combination therapy - potential clinical relevance [PDF]
, 2020 Protein kinase CK2 inhibition has long been considered as an attractive anti-cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is frequently over-expressed in human tumours and its over-expression correlates with a ...
Borgo, Christian +3 more
core +1 more source
, 2022 This book includes concise information about the new findings in biomedicine and cellular and molecular ...
Abbas Jedariforoughi
core +1 more source
CYRI proteins: controllers of actin dynamics in the cellular ‘eat vs walk’ decision [PDF]
, 2023 Cells use actin-based protrusions not only to migrate, but also to sample their environment and take up liquids and particles, including nutrients, antigens and pathogens.
Machesky, Laura M.
core +1 more source
Cancer Science, Volume 111, Issue 6, Page 2132-2145, June 2020., 2020 We found that abemaciclib, a CDK4/6 inhibitor, exerted a potent cytocidal effect in cancer cell lines with an atypical cell death phenotype, which entailed formation of multiple cytoplasmic vacuoles, and both the formation of vacuoles and the induction of cell death were inhibited by V‐ATPase inhibitors.
Hirotsugu Hino +8 more
wiley +1 more source
Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones [PDF]
Cell Biology and Toxicology, 2016 Methuosis is a form of non-apoptotic cell death involving massive vacuolization of macropinosome-derived endocytic compartments, followed by a decline in metabolic activity and loss of membrane integrity. To explore the induction of methuosis as a potential therapeutic strategy for killing cancer cells, we have developed small molecules (indole-based ...
Nneka E, Mbah +2 more
openaire +2 more sources
Journal of Lipid Research, 2017 Sphingolipids (SLs) have been extensively investigated in biomedical research due to their role as bioactive molecules in cells. Here, we describe the effect of a SL analog, jaspine B (JB), a cyclic anhydrophytosphingosine found in marine sponges, on the
Francesca Cingolani +6 more
doaj +1 more source
Aptamer-Driven Toxin Gene Delivery in U87 Model Glioblastoma Cells
Frontiers in Pharmacology, 2021 A novel suicide gene therapy approach was tested in U87 MG glioblastoma multiforme cells. A 26nt G-rich double-stranded DNA aptamer (AS1411) was integrated into a vector at the 5′ of a mammalian codon-optimized saporin gene, under CMV promoter. With this
Luana di Leandro +11 more
doaj +1 more source
Preparation and Application of Cyclic Chiral Organoboron Compounds for the Stereoselective Synthesis of Vacquinol-1 Analogs, and Trisubstituted Cyclobutylboronates [PDF]
, 2020 Boron is a versatile atom in synthetic organic and medicinal chemistry. The formation of a variety of carbon-carbon and carbon-heteroatom bonds, and the ability to act as a pharmacophore makes boron a powerful tool in drug discovery.
McDonald, Rory
core +2 more sources