Results 71 to 80 of about 793 (162)
A new chalcone derivative with promising antiproliferative and anti-invasion activities in glioblastoma cells [PDF]
, 2021 Glioblastoma (GBM) is the most common and most deadly primary malignant brain tumor. Current therapies are not effective, the average survival of GBM patients after diagnosis being limited to few months.
Castro, Joana Isabel Martins Cosme Vieira +7 more
core +1 more source
Abstract Uveal melanoma (UM) is the most frequent primary intraocular malignancy in adults with high metastasis and mortality rate, whose effective therapeutic strategy is still in urgent need. Specifically, apoptosis-resistance is a great challenge for advanced UM patients, therefore novel therapeutic options targeting otherwise death modality,
Qiuyan Liu +6 more
openalex +2 more sources
Molecular Oncology, Volume 14, Issue 2, Page 347-362, February 2020., 2020 CK2 phosphorylates the N terminus of ECE1c, impairing its proteasome‐dependent degradation and promoting invasiveness in colorectal cancer cells. We show that lys‐6 is the ubiquitinated residue and its mutation to arginine confers super‐stability to ECE1c.
Pablo Pérez‐Moreno +9 more
wiley +1 more source
The autophagy inducer trehalose stimulates macropinocytosis in NF1-deficient glioblastoma cells
Cancer Cell International, 2022 Background Glioblastoma is a highly aggressive brain tumor. A big effort is required to find novel molecules which can cross the blood–brain barrier and efficiently kill these tumor cells.
Barbara Del Bello +3 more
doaj +1 more source
Molecular Plant Pathology, Volume 21, Issue 1, Page 38-52, January 2020., 2020 Summary Vacuolar processing enzymes (VPEs) play an important role during regular growth and development and defence responses. Despite substantial attempts to understand the molecular basis of plant–cyst nematode interaction, the mechanism of VPEs functioning during this interaction remains unknown.
Mateusz Labudda +7 more
wiley +1 more source
“Janus” efficacy of CX-5011: CK2 inhibition and methuosis induction by independent mechanisms
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020 Methuosis has been described as a distinctive form of cell death characterized by the displacement of large fluid-filled vacuoles derived from uncontrolled macropinocytosis. Its induction has been proposed as a new strategy against cancer cells. Small molecules, such as indole-based calchones, have been identified as methuosis inducers and, recently ...
D'Amore C. +6 more
openaire +2 more sources
Investigation of Methuosis in Glioblastoma Cell Lines in Response to Treatment with Novel Chalcones
The FASEB Journal, 2021 The knowledge of cell death mechanisms following cancer therapies is continuing to expand. What was formerly understood as either apoptotic or necrotic cell death has evolved with recent research into non‐classical cell death pathways. Our interest in non‐classical cell death pathways resulted from our recent investigations of synthetic chalcone ...
Laura Inbody +7 more
openaire +1 more source
Elucidating the mechanism of cell death by bacopaside II in triple-negative breast cancer [PDF]
, 2020 This item is only available electronically.Thesis (BHlthMSc(Hons)) -- University of Adelaide, Adelaide Medical School ...
Yeo, Kenny
core
Tumor targeting gold nanoparticles for delivery of RNA and DNA oligonucleotide therapies for glioblastoma. [PDF]
, 2023 Glioblastoma (GBM) brain tumors are highly aggressive gliomas due to genetic and cellular heterogeneity. Current GBM treatment consists of surgical resection of the tumor combined with radio- or chemo-therapies.
Allen, Nicholas
core +2 more sources
Inhibition of NPC1L1 disrupts adaptive responses of drug‐tolerant persister cells to chemotherapy
EMBO Molecular Medicine, 2022 Entering a drug‐tolerant persister (DTP) state of cancer cells is a transient self‐adaptive mechanism by which a residual cell subpopulation accelerates tumor progression. Here, we identified the acquisition of a DTP phenotype in multidrug‐resistant (MDR)
Zhe Zhang +12 more
doaj +1 more source