Results 161 to 170 of about 8,425 (182)
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Acta Medica Scandinavica, 1982
ABSTRACT. Six patients with myocarditis and hepatitis, attributed to an allergic reaction to methyldopa, are described. Granulomatous pneumonitis was also found in four of them.
J. G. M. Jordans +2 more
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ABSTRACT. Six patients with myocarditis and hepatitis, attributed to an allergic reaction to methyldopa, are described. Granulomatous pneumonitis was also found in four of them.
J. G. M. Jordans +2 more
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Journal of Toxicology: Clinical Toxicology, 1982
A case of methyldopa overdose, confirmed by quantitative blood analysis, is presented. The clinical manifestations were coma, hypothermia, hypotension, bradycardia, and dry mouth. This combination of clinical findings, previously considered characteristic of phenothiazines or tricyclic antidepressants poisoning, should also raise the suspicion of ...
Y, Shnaps +3 more
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A case of methyldopa overdose, confirmed by quantitative blood analysis, is presented. The clinical manifestations were coma, hypothermia, hypotension, bradycardia, and dry mouth. This combination of clinical findings, previously considered characteristic of phenothiazines or tricyclic antidepressants poisoning, should also raise the suspicion of ...
Y, Shnaps +3 more
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Methyldopa-induced pancreatitis
The American Journal of Digestive Diseases, 1978An acute febrile illness associated with gastrointestinal upset developed in a patient within one week after starting treatment with methyldopa. The illness was characterized by prompt subsidence of symptoms when the patient withdrew therapy secondary to gastrointestinal upset, and recrudescence of symptoms when methyldopa therapy was reinitiated. This
Jorge G. Gutierrez +3 more
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The Renal Excretion of Methyldopa
Scandinavian Journal of Clinical and Laboratory Investigation, 1972The renal excretion of unconjugated methyldopa was studied in 17 patients on long-term therapy and in 7 patients following intravenous injection of 200 mg of the drug. The renal clearance of the conjugated drug was also determined in 9 cases. The renal function of the patients ranged from normal to severely impaired; even a patient with total anuria ...
Brodwall Ek +3 more
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Hypertensive Responses to Methyldopa
New England Journal of Medicine, 1966SEVERAL of the drugs currently employed in the management of arterial hypertension interfere with either the binding or the catabolism of norepinephrine in tissues. Administration of these drugs occasionally results in dangerous paradoxical pressor reactions.
Barry S. Strauch, Robert J. Levine
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METHYLDOPA AND HÆMOLYTIC ANÆMIA
Medical Journal of Australia, 1966William J. Louis +3 more
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European Journal of Clinical Pharmacology, 1975
The plasma concentrations of free alpha-methyldopa and methyldopa sulphate conjugate were measured in 7 hypertensive patients with normal renal function following alpha-methyldopa (1 g) orally. Five of these patients subsequently received alpha-methyldopa ethyl ester (250 mg) (methyldopate) intravenously and two further patients received 250 mg of ...
J A Saavedra +4 more
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The plasma concentrations of free alpha-methyldopa and methyldopa sulphate conjugate were measured in 7 hypertensive patients with normal renal function following alpha-methyldopa (1 g) orally. Five of these patients subsequently received alpha-methyldopa ethyl ester (250 mg) (methyldopate) intravenously and two further patients received 250 mg of ...
J A Saavedra +4 more
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Methyldopa kinetics before and after ingestion of methyldopa for eight weeks
European Journal of Clinical Pharmacology, 1995Methyldopa urine and plasma levels and urine metabolite levels were assessed following intravenous (IV) and oral (PO) methyldopa before, and after ingestion of methyldopa (500 mg) daily for eight weeks. There was no increase in (estimated) methyldopa absorption (8.4%) or renal clearance (PO 13.9%, IV 2.33%) after the eight weeks of methyldopa ingestion.
Yun K. Tam +4 more
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Effects of Methyldopa in Hypertension
JAMA, 1964Methyldopa demonstrated antihypertensive activity when prescribed in initial amounts of 1 gm daily in four divided doses to 51 patients with mild to moderate hypertension. The mean arterial pressure was reduced by an average of 34/18 mm Hg in the supine position and 34/24 mm Hg in the standing position.
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