Results 41 to 50 of about 565,458 (146)

mRNA Lipid Nanoparticles for Cell Engineering in Vivo and in Vitro: Current Applications and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Schematic diagram of mRNA‐lipid nanoparticles (mRNA‐LNP) and its functional mechanisms, applications, and challenges in cell engineering. This figure details the structural composition of mRNA‐LNPs and the delivery strategy, highlighting three core challenges.
Lina Li, Menglan Wang, Xiuhan Ye, Zhiyan Liu, Yijing Duan, Xiaoming Chen, Yue Ouyang, Qibiao Wu, Mengjuan Sun, Tian Xie   +9 more
wiley   +1 more source

Methylmalonic acid, a biochemical hallmark of methylmalonic acidurias but no inhibitor of mitochondrial respiratory chain.

, 2003
Methylmalonic acidurias are biochemically characterized by an accumulation of methylmalonic acid and alternative metabolites. An impairment of energy metabolism plays a key role in the pathophysiology of this disease, resulting in neurodegeneration of ...
Kolker, S., Okun, J.G., Smeitink, J.A.M., Horster, F., Sauer, S., Hoffmann, G.F., Hinz, A., Mayatepek, E., Wolf, N.I., Schwab, M.A., Jürgen G. Okun, Jan A.M. Smeitink, Ertan Mayatepek, Friederike Hörster, Stefan Kölker, Marina Schwab, Angela Hinz, Nicole I. Wolf, Georg F. Hoffmann, Sven Sauer   +19 more
core   +1 more source

The Topographical, Sensory, and Temporal Characteristics of Pain in Parkinson’s Disease: A Cross‐Sectional Survey

Pain Practice, Volume 26, Issue 4, April 2026.
ABSTRACT Background Pain in Parkinson's disease (PD) manifests clinically in a variety of ways and several pain types have been identified, however, their characteristics have not been extensively studied. Objective To describe the characteristics of common pain types in people with PD.
Anthony Mezzini, Saravana Kumar, Sue Sharrad, Joanne Harmon, Marion Eckert   +4 more
wiley   +1 more source

Elevated Serum Lipopolysaccharides and Intrinsic Factor Autoantibodies Correlate With Macrocytic Anemia Among People With HIV

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
ABSTRACT Introduction Human immunodeficiency virus (HIV) infection is associated with various comorbidities, including macrocytic anemia, though the role of the infection is unclear. HIV has been implicated in microbial translocation and altered immune responses.
Daniel Amakye, Samuel Hammond, Osbourne Quaye, Upal Roy, Peter Puplampu, Vincent Ganu, Emmanuel Ayitey Tagoe   +6 more
wiley   +1 more source

Neurological diagnoses in children potentially fulfilling the criteria for developmental coordination disorder

Developmental Medicine &Child Neurology, Volume 68, Issue 2, Page 251-262, February 2026.
In children potentially fulfilling the criteria for developmental coordination disorder (DCD), phenotypical assessment does not sufficiently predict the diagnostic outcome (i.e. DCD or an alternative diagnosis). Due to the lack of distinguishing clinical and diagnostic features and the high prevalence of genetic diagnoses in these patients, additional ...
Martinica Garofalo, Fleur Vansenne, Jessika F. van Hoorn, Marina A. J. Tijssen, Dineke S. Verbeek, Deborah A. Sival   +5 more
wiley   +1 more source

Enamel defects and salivary methylmalonate in methylmalonic acidemia [PDF]

, 2009
To characterize enamel defects in patients with methylmalonic acidemia (MMA) and cobalamin metabolic disorders and to examine salivary methylmalonate levels in ...
Bassim, C. W., Sloan, J., Guadagnini, J. P., Domingo, D. L., Venditti, C. P., Hart, T. C., Wright, J. T., Muralidharan, R.   +7 more
core   +1 more source

Prenatal diagnosis of 287 fetuses with a family history of methylmalonic aciduria.

, 2022
Prenatal diagnosis of 287 fetuses with a family history of methylmalonic aciduria.
Tongfei Wu (1693510), Mengqiu Li (1369623), Chunyan Shi (1416169), Hui Dong (153701), Yupeng Liu (396584), Ruxuan He (12292317), Lulu Kang (684986), Yao Zhang (134381), Jiong Qin (541838), Dongxiao Li (4860226), Jinqing Song (12292320), Yi Liu (36759), Yuan Ding (617135), Junya Chen (12328906), Ying Jin (107917), Yanling Yang (427399), Qiao Wang (174321), Yanyan Ma (2910716), Xiyuan Li (1307673), Zhehui Chen (12292314)   +19 more
core   +1 more source

Controlled‐Release Nanoparticles for the Treatment of Childhood Refractory Epilepsy in Latin America

BioMed Research International, Volume 2026, Issue 1, 2026.
Childhood refractory epilepsy (CRE) remains a major therapeutic challenge in Latin America, where limited access to specialized care, persistent treatment gaps, and high rates of pharmacoresistance contribute to poor clinical outcomes. This review examines the potential of sol‐gel–derived silica and titania nanoparticles as controlled‐release platforms
Tessy López-Goerne, Abel Santamaria, Antonela Gonzalez-Bondani, Rafael Valiente, Francisco Osuna-Orozco, Natalia Beltrán-Peña, Dulce Gurgua   +6 more
wiley   +1 more source

Orthopedic Intervention in an Organic Acid Disorder: Challenges in the Management of Hip Dislocation in a Child with Late Onset Methylmalonic Acidemia

Journal of Orthopaedic Case Reports
Introduction: Hip dislocation is a rare secondary complication due to neuromuscular dysfunction in organic acid disorders like methylmalonic acidemia (MMA). Surgical intervention in patients with metabolic-driven basal ganglia lesions present with unique
David Gregg Smith Ponraj, C Sitsabesan, P Gopinath Menon, Ranjith Kumar Manokaran, R Lakshmi Narasimhan   +4 more
doaj   +1 more source

Intracellular Cobalamin Defect in Early Infancy: A Cause of Hypotonia and Cytopenias

Case Reports in Medicine, Volume 2026, Issue 1, 2026.
Intracellular cobalamin metabolism defects (ICMDs) are rare but inherited disorders that disrupt the conversion of cobalamin into its active cofactors, methylcobalamin and adenosylcobalamin. We report a 40‐day‐old female infant with progressive hypotonia, poor feeding, hydrocephalus, and pancytopenia, whose metabolic profile demonstrated severe ...
Maryam Saeedi, Razieh Sangsari, Parastoo Rostami, Kayvan Mirnia, Sedigheh Shams, Sepideh Rahmati, Semonti Nandi   +6 more
wiley   +1 more source