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Pharmacokinetics of Methylprednisolone, Methylprednisolone Sodium Succinate, and Methylprednisolone Acetate in Dogs

Journal of Pharmaceutical Sciences, 1986
The absolute bioavailability and pharmacokinetic parameters of two methylprednisolone formulations (methylprednisolone sodium succinate and methylprednisolone acetate) were determined in five dogs. Plasma concentrations of methylprednisolone, methylprednisolone sodium succinate, and methylprednisolone acetate were measured by sensitive and specific ...
P L, Toutain   +3 more
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Hydrolysis of methylprednisolone hemisuccinate to methylprednisolone by a nonspecific carboxylesterase

Pharmacological Research Communications, 1980
Summary Enzymatic hydrolysis of methylprednisolone hemisuccinate with a non-specific carboxylesterase from hog liver was examined. The carboxyl-exterase was found to be useful in hydrolyzing methylprednisolone hemisuccinate to methylprednisolone.
T, Oshima, E, Nakajima, K, Hattori
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Methylprednisolone anaphylaxis

The American Journal of Emergency Medicine, 1999
The exacerbation of asthma is a problem frequently encountered by emergency physicians. In addition to oxygen and beta adrenergic agonists, oral and intravenous corticosteroids are increasingly being used to alleviate bronchospasm and to prevent recurrence of dyspnea.
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