Results 151 to 160 of about 4,160 (205)
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Methysergide in the Prophylaxis of Migraine
Lancet, The, 1964I Mackenzie, Ian Mackenzie, J D Williams
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Cephalalgia, 1998
Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist. Open and controlled studies attest to methysergide's efficacy. It may be more effective in resistant cases
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Methysergide is a semisynthetic ergot alkaloid ergometrine derivative, introduced in pharmacotherapy for migraine prophylaxis as a specific serotonin (5HT) receptor antagonist. Methysergide is not just a 5HT2 antagonist, it is also a 5HT1 agonist. Open and controlled studies attest to methysergide's efficacy. It may be more effective in resistant cases
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The Lancet, 1968
I HAVE proposed a comprehensive theory of cerebral amine function which links biochemical, physiological, psychological and clinical phenomena1,2. One hypothesis derived from this general theory is that methysergide should benefit patients with mania. The results of trials in the first five patients are sufficiently notable for a preliminary account to
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I HAVE proposed a comprehensive theory of cerebral amine function which links biochemical, physiological, psychological and clinical phenomena1,2. One hypothesis derived from this general theory is that methysergide should benefit patients with mania. The results of trials in the first five patients are sufficiently notable for a preliminary account to
openaire +3 more sources
Methysergide in the migraine syndrome
Clinical Pharmacology & Therapeutics, 1964Methysergide and a placebo were compared under double‐blind conditions for prophylactic effect in patients exhibiting the migraine syndrome. Each patient received in randomized order 2 mg. methysergide, three times a day orally for 5 consecutive weeks, and an identical placebo taken in the same way during another period of 5 weeks.
R B, SHEKELLE, A M, OSTFELD
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Methysergide in migraine prophylaxis
Clinical Pharmacology & Therapeutics, 1966In a clinical trial, methysergide and placebo were compared by the double‐blind method. The study was arranged so that it was also possible to assess the effect of methysergide and that of placebo in relation to the pre‐experimental condition. A dose of 6 mg. of methysergide was given to adult patients daily.
E, Pedersen, C E, Moller
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History of Methysergide in Migraine
Cephalalgia, 2008Harold Wolff's theory of vasodilation in migraine is well-known. Less known is his search for a perivascular factor that would damage local tissues and increase pain sensitivity during migraine attacks. Serotonin was found to be among the candidate agents to be included.
P J, Koehler, P C, Tfelt-Hansen
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Trial of Methysergide in Mania
Nature, 1968SEVERAL observations1,2 suggest that the metabolism of indoles, particularly 5-hydroxytryptamine (serotonin), is disturbed in affective illness. The introduction of methysergide as a potent and specific antiserotonin agent suggests possible applications in affective illness.
L, Haskovec, K, Soucek
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Methysergide as a Treatment for Mania
American Journal of Psychiatry, 1970Reports of dramatically successful treatment of acute mania with methysergide led the authors to undertake a small study. Twelve patients with acute mania were treated with doses of methysergide that had been reported to be effective. Only one patient recovered; all the others required further therapy.
M S, McCabe, T, Reich, G, Winokur
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