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Pharmacokinetics of Metoclopramide in Neonates
The Journal of Clinical Pharmacology, 1998Despite its wide use as a prokinetic agent in neonates and infants with gastroesophageal reflux (GER), the pharmacokinetics of metoclopramide have not been characterized in this pediatric subpopulation. A single‐dose pharmacokinetic study of oral metoclopramide (0.1 to 0.15 mg/kg) was performed in 10 fasted premature infants (weight 1.1 to 3.2 kg ...
Jeffrey L. Blumer +4 more
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Metoclopramide and Secondary Hyperaldosteronism
Annals of Internal Medicine, 1983Excerpt To the editor: Albibi and McCallum (1) recently reviewed the pharmacologic aspects and clinical applications of metoclopramide.
Mazzacca G +2 more
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Annals of Internal Medicine, 1985
Excerpt To the editor: Several drugs are known to cause bronchospasm (1), and the mechanisms responsible for this effect are many.
Dennis Jerome +2 more
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Excerpt To the editor: Several drugs are known to cause bronchospasm (1), and the mechanisms responsible for this effect are many.
Dennis Jerome +2 more
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Metoclopramide-Induced Parkinsonism
Southern Medical Journal, 1989Metoclopramide hydrochloride (Reglan) is a widely prescribed drug for treatment of upper gastrointestinal symptoms. Although the drug is relatively safe, a growing body of literature has noted movement disorders after its administration. We have reported six cases of metoclopramide-induced parkinsonism seen in consultation over a two-year period.
Kapil D. Sethi +2 more
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Current Medical Research and Opinion, 1975
Metaclopramide has been observed to induce dramatic relief of intractable hiccup in 14 patients with diverse serious illnesses. When given orally or parenterally the effect was observed within 30 minutes, the relief lasting up to 8 hours, indicating a direct relation to the duration of action of the drug. This drug is recommended for symptomatic relief
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Metaclopramide has been observed to induce dramatic relief of intractable hiccup in 14 patients with diverse serious illnesses. When given orally or parenterally the effect was observed within 30 minutes, the relief lasting up to 8 hours, indicating a direct relation to the duration of action of the drug. This drug is recommended for symptomatic relief
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Pharmacokinetics of metoclopramide in goats
Journal of Veterinary Pharmacology and Therapeutics, 1992The pharmacokinetics of a parenteral formulation of metoclopramide (mono‐chloride monohydrate) were determined following single intravenous (i.v.) and intramuscular (i.m.) 0.5‐mg/kg doses to two groups of 4 goats in a crossover design. Mean serum concentrations of metoclopramide following i.v. administration of 0.5 mg/kg declined rapidly from a peak of
J. C. Huhn +3 more
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Metoclopramide for Gastroparesis Diabeticorum
Diabetes Care, 1978Three patients with uncontrolled diabetes mellitus and with symptoms due to gastric retention proved to have gastroparesis diabeticorum. The diagnosis was established by the beefsteak-barium meal. After the administration of metoclopramide, gastric emptying improved and the diabetes was easily controlled.
A Bogoch, D Braverman
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The Use of Metoclopramide in the Elderly
Gerontologia Clinica, 1972118 patients receiving metoclopramide for a variety of symptoms were studied. The drug was effective in relieving nausea and vomiting caused by centrally acting emetics such as morphine and digitalis. It was also effective when these symptoms were due to locally acting factors in the upper gastro-intestinal tract, such as peptic ulcer.
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Diltiazem and Metoclopramide Overdose
Journal of Analytical Toxicology, 1991A fatality resulting from the suicidal ingestion of diltiazem and metoclopramide is described. The decedent was a 25-year-old female with a history of alcoholism and cocaine abuse who overdosed on her mother's medications. On admission she was bradycardiac with severe hypotension and third-degree heart block which progressed to asystole.
Jeanne M. Beno, Donna R. Nemeth
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Annals of Internal Medicine, 1985
Excerpt To the editor: In their letter on metoclopramide and depression, Bottner and Tullio (1) recommend gradual dosage increases for patients manifesting depression while taking metoclopramide.
Carl J. Tullio, Randy K. Bottner
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Excerpt To the editor: In their letter on metoclopramide and depression, Bottner and Tullio (1) recommend gradual dosage increases for patients manifesting depression while taking metoclopramide.
Carl J. Tullio, Randy K. Bottner
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