Results 281 to 290 of about 70,021 (330)
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Clinical Pharmacokinetics of Metoprolol
Clinical Pharmacokinetics, 1980Metoprolol is absorbed over a large part of the intestine and over 95% of an oral therapeutic dose is generally recovered in the urine as unchanged drug and metabolites. Presystemic elimination accounts for about 50% degradation of acutely administered oral doses.
Carl-Gunnar Regårdh, Gillis Johnsson
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Critical Care Medicine, 1985
A patient with an apparent dilantin and phenobarbital overdose displayed hypotension and oliguria resistant to usual cardiotonic drugs and volume loading. In addition, she required an unusually high dose of epinephrine for resuscitation. Metoprolol, a beta-blocker not included on the drug screen, was subsequently implicated.
Bekes Ce, Scott We
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A patient with an apparent dilantin and phenobarbital overdose displayed hypotension and oliguria resistant to usual cardiotonic drugs and volume loading. In addition, she required an unusually high dose of epinephrine for resuscitation. Metoprolol, a beta-blocker not included on the drug screen, was subsequently implicated.
Bekes Ce, Scott We
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Toxicological studies on metoprolol *
Acta Pharmacologica et Toxicologica, 1975Abstract:This paper presents a review of the toxicological studies in animals on metoprolol ‐ a cardioselective β‐blocking agent. Studies after single administration were performed in mice, rats and dogs. LD50‐values were calculated for the rodents while maximum tolerated dose was estimated for the dogs.
Göran Magnusson +4 more
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Journal of Analytical Toxicology, 1984
Metoprolol, a beta 1-adrenergic blocking agent, has been found effective in the treatment of hypertension. A death due to deliberate ingestion of metoprolol is described, including the case history, postmortem toxicologic findings, and identification and quantitation of the drug by high pressure liquid chromatography and gas chromatography/mass ...
J C Beyer, R H Granger, M Stajić
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Metoprolol, a beta 1-adrenergic blocking agent, has been found effective in the treatment of hypertension. A death due to deliberate ingestion of metoprolol is described, including the case history, postmortem toxicologic findings, and identification and quantitation of the drug by high pressure liquid chromatography and gas chromatography/mass ...
J C Beyer, R H Granger, M Stajić
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International Journal of Cardiology, 1987
Metoprolol caused a significant (P less than 0.001) increase in urine output in rabbits. There was no change in serum sodium concentration but serum potassium levels increased significantly. The most probable mechanism of action was increase in renal blood flow and glomerular filtration rate.
S. Vanjani, S.R. Mittal, A.K. Mathur
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Metoprolol caused a significant (P less than 0.001) increase in urine output in rabbits. There was no change in serum sodium concentration but serum potassium levels increased significantly. The most probable mechanism of action was increase in renal blood flow and glomerular filtration rate.
S. Vanjani, S.R. Mittal, A.K. Mathur
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Is Metoprolol CR/ZOK More Selective Than Conventional Metoprolol and Atenolol?
The Journal of Clinical Pharmacology, 1990An alternative, simple method to assess beta1‐selectivity is to establish the impact of the beta blocker on beta2‐stimulated increases in plasma glucose and decreases in plasma potassium during an intravenous infusion of terbutaline. In the present study the effects of metoprolol CR/ZOK 100 mg, conventional metoprolol 100 mg, atenolol 100 mg, and ...
Beverly Hughes +3 more
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, 2000
For editorial comment see p 1335. Context Results from recent studies on the effects of b1-blockade in patients with heart failure demonstrated a 34% reduction in total mortality.
A. Hjalmarson +22 more
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For editorial comment see p 1335. Context Results from recent studies on the effects of b1-blockade in patients with heart failure demonstrated a 34% reduction in total mortality.
A. Hjalmarson +22 more
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Mental Testing With Metoprolol
Archives of Internal Medicine, 1989To the Editor .—An article by Gengo and associates 1 that showed greater improvement in mental testing with metoprolol is consistent with earlier data not referenced in their article, which included a report by Eisdorfer ( Continued on page 474. ) ( Continued from page 472.
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Metoprolol in the treatment of cardiovascular disease: a critical reappraisal
Current Medical Research and Opinion, 2018Background: Extensive clinical experience on metoprolol has been gained in different cardiovascular conditions. Review: This paper discusses the use of metoprolol, with a focus on the extended-release formulation, in clinical practice in the light of ...
G. Grassi
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The effect of ionizing radiation on metoprolol
Drug Development and Industrial Pharmacy, 2012The influence of ionising radiation on physico-chemical properties of metoprolol tartrate (MT) in solid phase was studied. The compound was irradiated by radiation produced by a beam of high-energy electrons in an accelerator, in doses from 25 to 400 kGy, and the possible changes in the samples were detected by organoleptic analysis (colour, forms ...
Aleksandra Czwajda +2 more
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