Results 51 to 60 of about 46,948 (287)
Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA
FEBS Open Bio, EarlyView.PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro +1 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source
Primary: Jurnal Pendidikan Guru Sekolah Dasar, 2015 Problem in the research was started from observation the author encountered in the field that many students have not been able to do 100 metre breaststroke swimming well. It could be seen when students did not finish 100 metre breaststroke swimming.
Saripin Saripin
doaj +1 more source
Historical Intimacy in Malay Urban Core Configurations: A Comparative Analysis
Culture & History Digital Journal, 2020 This paper analyses the historical pre-Colonial configurations of a series of urban cores in Malay sites along the Straits of Melaka. The objective of this research is to identify the pattern and variations of each pre-Colonial royal urban core from the ...
Illyani Ibrahim +2 more
doaj +1 more source
MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis
FEBS Open Bio, EarlyView.MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph +7 more
wiley +1 more source
Travel and leisure stocks' exposure to exchange rates
Annals of Tourism Research Empirical Insights, 2023 Dlawar Mahdi Hadi
doaj +1 more source
Bohuslav Tablica's Literary Terminology II. The Concept of Poetic Art and Its Variants in the Context of Tablica's Literary-Historical Reflections [PDF]
Slovenska Literatura, 2010 Tablic used several variants of terms to determine poetic activity. He characterized ability of authors to write in verse form and according to the poetic rules. That way he depicted poetic activity and distinguished it from other types of literary works.
Lenka Rišková
doaj
Optimizing photoexcitation conditions for time‐resolved X‐ray solution scattering experiments
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering (TR‐XSS) is a powerful technique to visualize how proteins change their structure in real time after light activation. Selecting the right laser photoexcitation conditions—fluence, excitation geometry, and sample refresh rate—is critical to maximize the experimental signal while avoiding unwanted side effects ...
Matteo Levantino
wiley +1 more source
Evolution‐guided yeast complementation reveals functional differences in human PSPH variants
FEBS Open Bio, EarlyView.Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez +6 more
wiley +1 more source