Is the whole more than the sum of its parts? Considering global and local features of the connectome improves prediction of individuals and phenotypes. [PDF]
Riley S +8 more
europepmc +1 more source
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Gamma Knife treatment planning using knowledge-based reinforcement learning. [PDF]
Huynh C +5 more
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Low-Cost RGB-D Sensing Front-End for Stable 3D Hand Landmark Reconstruction Using MediaPipe and ZED2 Stereo Depth. [PDF]
Peng L, Liu T, He B.
europepmc +1 more source
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Impact of Missing Data and Monitoring Duration on Downstream Analyses in Continuous Glucose Monitoring. [PDF]
Kok N +3 more
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Multispecies Niche Overlap: Moving Beyond Pairwise Metrics to Understand Community-Wide Similarities in Resource Use. [PDF]
Kent CM, Powell S, Sherry TW.
europepmc +1 more source

