Results 91 to 100 of about 70,935 (267)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Conformal Ricci soliton in Sasakian manifolds admitting general connection [PDF]

Journal of Hyperstructures
The object of the present paper is to study the Conformal Ricci soliton in Sasakian manifold admitting general connection, which is induced with quarter symmetric metric connection, generalized Tanaka Webster connection, Schouten-Van Kampen connection ...
Raghujyoti Kundu, Ashoke Das, Ashis Biswas   +2 more
doaj   +1 more source

Quarter - symmetric metric connection on ? (?,?) - contact metric manifold

Communications, Faculty Of Science, University of Ankara Series A1Mathematics and Statistics, 2006
The object of the present paper is to prove the existence of a guarter-symmetric metric connection on a Riemannian manifold and to study some properties of a guarter-symmetric metric connection on a non-Sasakian (fc,/z)-contact metric manifold.
SANJIB KUMAR JANA, A. A. SHAIKH
openaire   +2 more sources

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The Relation Between the Associate Almost Complex Structure to HM' and (HM',S,T)-Cartan Connections

Symmetry, Integrability and Geometry: Methods and Applications, 2006
In the present paper, the (HM',S,T)-Cartan connections on pseudo-Finsler manifolds, introduced by A. Bejancu and H.R. Farran, are obtained by the natural almost complex structure arising from the nonlinear connection HM'. We prove that the natural almost
Ebrahim Esrafilian, Hamid Reza Salimi Moghaddam   +1 more
doaj  

Characterizations of a warped product manifold admitting semi-symmetric recurrent metric connection with applications

European Physical Journal C: Particles and Fields
This research focuses on warped product manifolds equipped with a semi-symmetric recurrent metric connection. It explores the geometric properties and implications of these warped product manifolds.
Hülya Bağdatlı Yılmaz, Uday Chand De, Aydin Gezer   +2 more
doaj   +1 more source

On Concircular 𝜙-Recurrent 𝐾-Contact Manifold Admitting Semisymmetric Metric Connection

International Journal of Mathematics and Mathematical Sciences, 2012
In the present paper, we have studied 𝜙-recurrent and concircular 𝜙-recurrent 𝐾-contact manifold with respect to semisymmetric metric connection and obtained some interesting results.
Venkatesha, K. T. Pradeep Kumar, C. S. Bagewadi, Gurupadavva Ingalahalli   +3 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source