Results 171 to 180 of about 6,611,973 (350)
Communications in Mathematical Physics, 1973 The set of allC 2 Lorentz metrics on a non-compact four-manifold is given the Whitney fineC 2 topology. It is shown that this provides the correct framework within which to discuss the global properties of spacetime manifolds in general, and the singularity theorems in particular. The main result is a theorem showing that the Robertson-Walker big bang (
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Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation
Molecular Oncology, EarlyView.Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides +13 more
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On eigenvectors of compact contractions acting in linear metric spaces [PDF]
, 1968 J. Halperin, S. Rolewicz, A. L. Shields
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Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
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Differentiable fibre spaces and mappings compatible with Riemannian metrics. [PDF]
, 1964 Joseph A. Wolf
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Molecular Oncology, EarlyView.Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban +12 more
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Decrypting cancer's spatial code: from single cells to tissue niches
Molecular Oncology, EarlyView.Spatial transcriptomics maps gene activity across tissues, offering powerful insights into how cancer cells are organised, switch states and interact with their surroundings. This review outlines emerging computational, artificial intelligence (AI) and geospatial approaches to define cell states, uncover tumour niches and integrate spatial data with ...
Cenk Celik +4 more
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A fixed point theorem of the alternative, for contractions on a generalized complete metric space [PDF]
, 1968 J. B. Díaz, Beatriz Margolis
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Molecular Oncology, EarlyView.Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun +5 more
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Fixed point theorems for nonlinear contractive mappings in ordered b-metric space with auxiliary function. [PDF]
BMC Res Notes, 2020 Seshagiri Rao N, Kalyani K, Mitiku B.
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