Results 41 to 50 of about 998,991 (321)
The nature of ligand efficiency
Journal of Cheminformatics, 2019 Ligand efficiency is a widely used design parameter in drug discovery. It is calculated by scaling affinity by molecular size and has a nontrivial dependency on the concentration unit used to express affinity that stems from the inability of the ...
Peter W. Kenny
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou +10 more
wiley +1 more source
The biharmonic homotopy problem for unit vector fields on 2-tori
, 2018 The bienergy of smooth maps between Riemannian manifolds, when restricted to unit vector fields, yields two different variational problems depending on whether one takes the full functional or just the vertical contribution. Their critical points, called
Loubeau, E., Markellos, M.
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FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
On non-commutative Minkowski spheres
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2012 The purpose of the following is to try to make sense of the stereo- graphic projection in a non-commutative setup. To this end, we consider the open unit ball of a ternary ring of operators, which naturally comes equipped with a non-commutative version ...
Stachó Lászlo L., Werner Wend
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FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Complexity measure based on sensitivity analysis applied to an intensive care unit system
Scientific Reports, 2023 This work proposes a system complexity metric and its application to Intensive Care Unit (ICU) system. The methodology for applying said complexity metric comprises: (i) parameters sensitivity indices calculation, (ii) mapping connections dynamics ...
Joao R. B. Paiva +7 more
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FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
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Characterization of Clifford Torus in Three-Spheres
Mathematics, 2020 We characterize spheres and the tori, the product of the two plane circles immersed in the three-dimensional unit sphere, which are associated with the Laplace operator and the Gauss map defined by the elliptic linear Weingarten metric defined on closed ...
Dong-Soo Kim, Young Ho Kim, Jinhua Qian
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, 2016 The Bohr inequality, first introduced by Harald Bohr in 1914, deals with finding the largest radius $r ...
A. Aytuna +53 more
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