Results 201 to 210 of about 2,496,702 (337)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Lower bounds on the minimum distance of long codes in the Lee metric

, 2013
Hugues Randriam, Lin Sok, Patrick Solé
openalex   +1 more source

Life’s Simple 7 Cardiovascular Health Metrics and Progression of Coronary Artery Calcium in a Low-Risk Population [PDF]

, 2019
Seolhye Kim, Yoosoo Chang, Juhee Cho, Yun Soo Hong, Di Zhao, Jeonggyu Kang, Hyun Suk Jung, Kyung Eun Yun, Eliseo Güallar, Seungho Ryu, Ho Cheol Shin   +10 more
openalex   +1 more source

Methodological Development and Assessing Prescribing Determinants Through Cumulative Drug Exposure in Hospitalized Patients: Proof-of-Concept Retrospective Study.

JMIR Med Inform
Bories M, Bouzillé G, Cuggia M, Le Corre P, Bannay A.   +4 more
europepmc   +1 more source

Pitch Performance After Ulnar Collateral Ligament Surgery in Major League Baseball Pitchers. [PDF]

Orthop J Sports Med
Mastroianni MA, Kunes JA, Dillon MR, Chen AZ, Luzzi AJ, LeVasseur MR, Danaher MJ, Alexander FJ, Ahmad CS.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Arterial Stiffness: Different Metrics, Different Meanings [PDF]

, 2019
Bart Spronck, J. D. Humphrey
openalex   +1 more source

Family Physicians' Views of Who They Are Accountable To and Current Quality Metrics.

JAMA Netw Open
Young RA, Burge SK, Bergs KS, Residency Research Network of Texas (RRNeT) Investigators group.   +3 more
europepmc   +1 more source

A multi-metric evaluation of readability in psychiatric discharge summaries. [PDF]

BioData Min
Li F, Taylor CO, Zirikly A.
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source