Results 41 to 50 of about 496,296 (202)

The effect of brown algae (Sargassum sp.) gel on the number of osteoclasts in periodontitis rats

Padjadjaran Journal of Dentistry, 2022
Introduction: Alveolar bone resorption in periodontitis is caused by increased activation of osteoclasts, causing an imbalance of bone remodeling.
Muhamat Muhtar S. Abdurrohman, Rahmawati Sri Praptiningsih, Yulistinawati Yulistinawati   +2 more
doaj   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

Oligosaccharides With Defined Glycosidic Bonds Shape Gut Microbial Succession and Metabolism Via Bond‐Specific Microbial Responders

Advanced Science, EarlyView.
Oligosaccharides with defined glycosidic bonds drive divergent gut microbial succession and shape unique metabolic profiles. Absolute time‐series profiling with Bayesian generalized Lotka–Volterra modeling identifies bond‐specific microbial responders, while monoculture validation and metaproteomics reveal linkage‐matched transport and cleavage modules.
Xiaoxuan Lu, Jiaqi Zou, Geng Han, Mengyao Zhao, Ting Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji, Jiayang Jin, Liming Zhao   +10 more
wiley   +1 more source

Nitroimidazole action in Entamoeba histolytica: a central role for thioredoxin reductase. [PDF]

PLoS Biology, 2007
Metronidazole, a 5-nitroimidazole drug, has been the gold standard for several decades in the treatment of infections with microaerophilic protist parasites, including Entamoeba histolytica. For activation, the drug must be chemically reduced, but little
David Leitsch, Daniel Kolarich, Iain B H Wilson, Friedrich Altmann, Michael Duchêne   +4 more
doaj   +1 more source

Pathological Signal‐Responsive Nanoplatforms for Sepsis: Integrating Biomarker Sensing With Spatiotemporal Drug Delivery and Immunomodulation

Advanced Science, EarlyView.
Biomarker‐triggered nanoplatforms transform sepsis therapy by coupling pathological sensing with precision drug release. This review reveals how microenvironment‐responsive nanomedicines enable stage‐specific intervention, improve therapeutic efficacy, and minimize systemic toxicity, while highlighting emerging opportunities for AI‐assisted and ...
Yukun Liu, Kang Wang, Kwet Kyawl Yan, Zhikai Xu, Xuan Zhao, Xiangjun Bai, Zhanfei Li, Yuchang Wang   +7 more
wiley   +1 more source

A New Controlled-Release Material Containing Metronidazole and Doxycycline for the Treatment of Periodontal and Peri-Implant Diseases: Formulation and In Vitro Testing

International Journal of Dentistry, 2019
Background. Several locally administered antimicrobials have been studied in the literature as adjunctive or primary treatments for periodontitis and peri-implantitis with conflicting results. Objective.
Livia Nastri, Alfredo De Rosa, Vincenza De Gregorio, Vincenzo Grassia, Giovanna Donnarumma   +4 more
doaj   +1 more source

An in vitro comparative evaluation of the antibacterial efficacy of 10% metronidazole gel, 2% chlorhexidine gel, and a combination of calcium hydroxide and 2% chlorhexidine gel against Enterococcus faecalis

Journal of Orofacial Sciences, 2012
Background and Objectives: A major objective in endodontic therapy is to disinfect the root canal system prior to obturation. This is because the residual root canal infection can sustain persistent or recurrent periapical disease.
Jaya Nagendra Krishna, Ramya Raghu, Nagesh Bolla, Keerthi Muddanna   +3 more
doaj   +1 more source

Z‐Scheme BiOCl‐Based Photocatalysts: Recent Advances in Designing, Structural Engineering, Formation Mechanisms, and High Performance Photocatalytic Environmental Remediation

EcoEnergy, EarlyView.
This review deals with the recent advancements in design and engineering of BiOCl‐based Z‐scheme photocatalysts with emphasis on tailoring of structural, optoelectronic properties and heterojunction assembly for environmental applications including photodegradation of industrial organic waste, pharmaceuticals, pesticides, herbicides, toxic heavy metals,
Sakshi Sharma, Neha Kaushal, Victor Ezebuiro, Monika Sindhu, Lovepreet Singh, Yugesh Singh Thakur, Hendrik C. Swart, Jai Prakash   +7 more
wiley   +1 more source

Subgingival application of 25% metronidazole gel, 1% chlorhexidine gel as adjunctive therapy to scaling and root planing in treatment of chronic periodontitis

Sulaimani Dental Journal, 2015
Objectives: The aim of this study was to compare the clinical effect of subgingival application of 25% metronidazole gel or 1% chlorhexidine gel as an adjunctive to scaling and root planing over a root planing alone. Materials and Methods: Ten adults (
Shokhan Abdullah Karim, Basima Ghafury Ali, Kamal Ahmed Saeed   +2 more
doaj   +1 more source

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4/Myd88/MAPK Pathway Inhibition

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits.
Lijing Du, Shikai Yan, Xiaopeng Ren, Syed Shams ul Hassan, Yuanfang Sun, Yu Gan, Xue Xiao, Shasha Li, Huizi Jin   +8 more
wiley   +1 more source