Results 111 to 120 of about 17,948 (248)

Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells [PDF]

, 2005
[Abstract] Glutamate is thought to be the excitatory neurotransmitter in the lateral geniculate nucleus (LGN) of the cat, mediating visual transmission from the retina via ionotropic receptors of both d,l-α-amino-3-hydroxy-5-α-methyl-4 ...
Cudeiro, Javier, Labra, Carmen de, Rivadulla, Casto   +2 more
core   +2 more sources

Multimodal spatial gradients to explain regional susceptibility to fibrillar tau in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 5, May 2025.
Abstract INTRODUCTION In Alzheimer's disease (AD), fibrillar tau gradually progresses from initial seed to larger brain area. However, those brain properties underlying the region‐dependent susceptibility to tau accumulation remain unclear. METHODS We constructed multimodal spatial gradients to characterize molecular properties and connectomic ...
Ying Luan, Lukai Zheng, Jannis Denecke, Amir Dehsarvi, Sebastian N. Roemer‐Cassiano, Anna Dewenter, Anna Steward, Sergey Shcherbinin, Diana Otero Svaldi, Vikas Kotari, Ixavier Alonzo Higgins, Michael J. Pontecorvo, Carolina Valentim, Julia A. Schnabel, Francesco Paolo Casale, Martin Dyrba, Stefan Teipel, Nicolai Franzmeier, Michael Ewers, for the Alzheimer's Disease Neuroimaging Initiative (ADNI)   +19 more
wiley   +1 more source

Controlled trial of lovastatin combined with an open-label treatment of a parent-implemented language intervention in youth with fragile X syndrome. [PDF]

, 2020
BackgroundThe purpose of this study was to conduct a 20-week controlled trial of lovastatin (10 to 40 mg/day) in youth with fragile X syndrome (FXS) ages 10 to 17 years, combined with an open-label treatment of a parent-implemented language intervention (
Abbeduto, Leonard, Banasik, Amy, Bullard, Lauren, Hagerman, Randi, Kim, Kyoungmi, McDuffie, Andrea, Nguyen, Vivian, Potter, Laura A, Potter, Sarah Nelson, Tassone, Flora, Thurman, Angela John   +10 more
core  

mGluR5 protect astrocytes from ischemic damage in postnatal CNS white matter [PDF]

, 2015
Astrocytes perform essential neuron-supporting functions in the central nervous system (CNS) and their disruption has devastating effects on neuronal integrity in multiple neuropathologies.
Butt, Arthur M., Vanzulli, Ilaria
core   +1 more source

Group i metabotropic glutamate receptors: A potential target for regulation of proliferation and differentiation of an immortalized human neural stem cell line [PDF]

, 2016
© 2014 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Human neural stem cells (NSCs) from the developing embryo or the subventricular zone of the adult brain can potentially elicit brain repair after injury or ...
Blaabjerg, Morten, Bogetofte, Helle, Erichsen, Julie L., Martínez-Serrano, Alberto, Meyer, Morten   +4 more
core   +1 more source

The prion protein constitutively controls neuronal store-operated ca2+ entry through Fyn Kinase [PDF]

, 2015
The prion protein (PrPC) is a cell surface glycoprotein mainly expressed in neurons, whose misfolded isoforms generate the prion responsible for incurable neurodegenerative disorders.
Agnese eDe Mario, Alessandro eBertoli, Andrew Francis Hill, Angela eCastellani, Caterina ePeggion, Dmitry eLim, Maria Catia eSorgato, Maria Catia eSorgato, Maria Lina eMassimino   +8 more
core   +4 more sources

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

PLoS Pathogens, 2017
Prion infections cause inexorable, progressive neurological dysfunction and neurodegeneration. Expression of the cellular prion protein PrPC is required for toxicity, suggesting the existence of deleterious PrPC-dependent signaling cascades.
Despoina Goniotaki, Asvin K K Lakkaraju, Amulya N Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi   +10 more
doaj   +1 more source

Metabotropic glutamate receptor 5 as a potential target for smoking cessation [PDF]

, 2016
Rationale Most habitual smokers find it difficult to quit smoking because they are dependent upon the nicotine present in tobacco smoke. Tobacco dependence is commonly treated pharmacologically using nicotine replacement therapy or drugs, such as ...
A Auber, A Markou, A Markou, A Markou, A Markou, AA Harrison, AJ Severance, AK Stoker, AL Milton, AL Milton, AR Caggiula, AR Caggiula, AW Ary, AY Bespalov, B Xiao, C Cadoni, C Chiamulera, C Romano, CA Heidbreder, CA Owesson-White, CJ Swanson, Claudio Marcello Marzo, CM Niswender, Cristiano Chiamulera, CW Hodge, D Hustonlyons, D Lecca, D Li, D Martinez, David J. K. Balfour, DH Malin, DJ Balfour, DJ Balfour, DJ Balfour, E Luccini, EL Kam van der, F Akkus, F Akkus, F Ferraguti, F Gasparini, F Nicoletti, FI Carroll, GN Pachas, HH Nickols, HS Crombag, JA O’Brien, JE Rose, JE Rose, JF Cryan, JH Kim, JM Arnold, JP Schroeder, JR Hughes, JT Gass, KK Szumlinski, L Hou, L Mu, LH Brauer, LM Hulka, M Louis, M Olive, M Parodi, M Tessari, MA Bozarth, MB Ghasemzadeh, ME Benwell, ME Liechti, ME Liechti, ME Liechti, MG LeSage, MI Palmatier, MI Palmatier, MP Epping-Jordan, MPH Osborne, MS D’Souza, MS Milella, MT Taber, N Chaudhri, N Chaudhri, ND Cosford, NE Paterson, NE Paterson, P Backstrom, P Welsby, PB Clarke, PBS Clarke, PJ Kenny, PJ Kenny, PR Brakeman, PW Kalivas, PW Kalivas, PW Kalivas, R Anwyl, R Rong, R Shigemoto, RD Peavy, RE Nordquist, RJ Cormier, RK Das, RL Pillai, RM Brown, RW Gould, S Kawabata, SA Kotecha, SA McKee, SB Floresco, SJ Tallaksen-Greene, SM Ametamey, SM Ametamey, T Agren, T Zhang, TM Keck, TM Marton, V Kumaresan, V Tedesco, V Tronci, V Tronci, VC Wing, X Li, X Liu, ZP Jia   +120 more
core   +2 more sources

Effect of age on brain metabotropic glutamate receptor subtype 5 measured with [18F]FPEB PET

NeuroImage, 2021
Objective: Metabotropic glutamate receptor subtype 5 (mGluR5) is integral to the brain glutamatergic system and cognitive function. This study investigated whether aging is associated with decreased brain mGluR5 availability.
Adam P. Mecca, Kelly Rogers, Zachary Jacobs, Julia W. McDonald, Hannah R. Michalak, Nicole DellaGioia, Wenzhen Zhao, Ansel T Hillmer, Nabeel Nabulsi, Keunpoong Lim, Jim Ropchan, Yiyun Huang, David Matuskey, Irina Esterlis, Richard E. Carson, Christopher H. van Dyck   +15 more
doaj  

Elevated CaMKIIα and Hyperphosphorylation of Homer Mediate Circuit Dysfunction in a Fragile X Syndrome Mouse Model

Cell Reports, 2015
Abnormal metabotropic glutamate receptor 5 (mGluR5) function, as a result of disrupted scaffolding with its binding partner Homer, contributes to the pathophysiology of fragile X syndrome, a common inherited form of intellectual disability and autism ...
Weirui Guo, Laura Ceolin, Katie A. Collins, Julie Perroy, Kimberly M. Huber   +4 more
doaj   +1 more source