Results 111 to 120 of about 20,586 (243)

A Novel Role of A2AR in the Maintenance of Intestinal Barrier Function of Enteric Glia from Hypoxia-Induced Injury by Combining with mGluR5 [PDF]

, 2021
Lihua Sun, Xiang Li, Haidi Guan, Shuaishuai Chen, Xin Fan, Chao Zhou, Hua Yang, Weidong Xiao   +7 more
openalex   +1 more source

Mimics and Diagnostic Pitfalls of Anti‐Adenylate Kinase 5 Limbic Encephalitis

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Mimics of anti‐AK5 encephalitis are common and that misdiagnosis is often driven by non‐specific symptoms and clinically irrelevant antibody results. The absence of cognitive impairment as a major symptom, prominence of psychiatric and behavioral symptoms, isolated from serum positivity or low CSF antibody titers (< 1:100), and objective clinical ...
Jierui Wang, Tong Yi, Guoyu Wang, Minjin Wang, Dong Zhou, Jinmei Li   +5 more
wiley   +1 more source

Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Acta Neuropathologica, 2015
Knockout of genes encoding metabotropic glutamate receptor 5 (mGluR5) or its endogenous regulators, such as Norbin, induce a schizophrenia-like phenotype in rodents, suggesting dysregulation of mGluR5 in schizophrenia. Human genetic and pharmacological animal studies support this hypothesis, but no studies have explored mGluR5 dysfunction at the ...
Matosin, Natalie, Fernandez-Enright, Francesca Elizabeth, Fung, Samantha Jane, Lum, Jeremy Stephen, Engel, Martin, Andrews, Jessica Lee, Huang, Xu-Feng, Weickert, Cynthia Shannon, Newell, Kelly Anne   +8 more
openaire   +5 more sources

Collaborative development of the Arrowsmith two node search interface designed for laboratory investigators. [PDF]

, 2006
Arrowsmith is a unique computer-assisted strategy designed to assist investigators in detecting biologically-relevant connections between two disparate sets of articles in Medline.
Bischoff-Grethe, Amanda, Burhans, Lauren B, Gabriel, Michael, Homayouni, Ramin, Kashef, Alireza, Martone, Maryann E, Perkins, Guy A, Price, Diana L, Smalheiser, Neil R, Talk, Andrew C, Torvik, Vetle I, West, Ruth   +11 more
core   +3 more sources

Glutamate Receptors and Synaptic Plasticity in Health and Disease: A Personal Journey

Hippocampus, Volume 36, Issue 1, January 2026.
ABSTRACT I describe my progress in understanding synaptic plasticity in the hippocampus. Over the decades my lab has focused on the roles of glutamate receptors (AMPARs, NMDARs, mGluRs and KARs) and associated signaling molecules in LTP and LTD. Most of our studies have been conducted in area CA1 (Schaffer collateral—commissural pathway) with some ...
Graham L. Collingridge
wiley   +1 more source

Genetic Reduction of the Translational Repressors FMRP and 4E‐BP2 Preserves Memory in Mouse Models of Alzheimer's Disease

Aging Cell, Volume 25, Issue 1, January 2026.
Genetic reduction of the translational repressors FMRP or 4E‐BP2 prevents amyloid‐β oligomer–induced suppression of hippocampal protein synthesis and memory loss in mice. Targeting translational control preserves cognitive function in Alzheimer's models, revealing mRNA translation as a promising therapeutic axis for memory preservation.
Felipe C. Ribeiro, Danielle Cozachenco, Michael Parkhill, Brandon Rodrigue, Caio Borges, Jean‐Claude Lacaille, Karim Nader, Fernanda G. De Felice, Mychael V. Lourenco, Argel Aguilar‐Valles, Nahum Sonenberg, Sergio T. Ferreira   +11 more
wiley   +1 more source

Long-lasting impairment of mGluR5-activated intracellular pathways in the striatum after withdrawal of cocaine self-administration [PDF]

, 2017
Background: Cocaine addiction continues to be a major heath concern, and despite public health intervention there is a lack of efficient pharmacological treatment options.
Ango, Estefanía Moreno, Fasano, Gould, Hanne Mette Hoffmann, Jordi Ortiz, Michel Vignes, Nadine Crouzin, Noora Raivio, Peter J. McCormick, Self, Silvia Fuentes, Sung, Swanson, Terbeck, Valjent   +15 more
core   +3 more sources

Dissociation of the mTOR Protein Interaction Network Following Neuronal Activation Is Altered by Shank3 Mutation

Journal of Neurochemistry, Volume 170, Issue 1, January 2026.
Neurons encode activity through precise, stimulus‐dependent rearrangements of protein interaction networks, including the mTOR signaling cascade. Using multiplex co‐immunoprecipitation in primary cortical neurons, we show that IGF1, glutamate, and homeostatic up‐ or down‐scaling with Tetrodotoxin (TTX) or Bicuculline (BIC), respectively, each induce ...
Devin T. Wehle, Emily A. Brown, Vera Stamenkovic, Breann Gniffen, Felicia M. Harsh, Stephen E. P. Smith   +5 more
wiley   +1 more source

Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice [PDF]

, 2015
Adult neurogenesis in the hippocampus subgranular zone is associated with the etiology and treatment efficiency of depression. Factors that affect adult hippocampal neurogenesis have been shown to contribute to the neuropathology of depression. Glutamate,
Enikolopov, G., Flajolet, M., Greengard, P., Varela, S., Wang, H., Warner-Schmidt, J.   +5 more
core   +1 more source

Metabotropic glutamate receptor 5 regulates synaptic plasticity in a chronic migraine rat model through the PKC/NR2B signal

The Journal of Headache and Pain, 2020
Background The mechanism of chronic migraine (CM) is complex, central sensitization is considered as one of the pathological mechanism. Synaptic plasticity is the basis of central sensitization.
Yingying Niu, Xiaoxu Zeng, Lilin Zhao, Yang Zhou, Guangcheng Qin, Dunke Zhang, Qingqing Fu, Jiying Zhou, Lixue Chen   +8 more
doaj   +1 more source