Results 131 to 140 of about 250,141 (320)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Presentación

Telos: Revista de Estudios Interdisciplinarios en Ciencias Sociales, 2009
Las revistas científicas se han convertido en los últimos años en la forma más sencilla y a la vez más compleja de comunicar los resultados de investigaciones llevadas acabo en nuestro quehacer investigativo, TELOS particularmente ha evolucionado con el ...
Mgs. Wileidys Artigas
doaj  

Turing Test, Chinese Room Argument, Symbol Grounding Problem. Meanings in Artificial Agents [PDF]

, 2012
The Turing Test (TT), the Chinese Room Argument (CRA), and the Symbol Grounding Problem (SGP) are about the question “can machines think?”. We propose to look at that question through the capability for Artificial Agents (AAs) to generate meaningful ...
Menant, Mr Christophe
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

New structure information on Mg-30, Mg-31 and Mg-32

, 2005
5 pages, 10 figures.-- PACS nrs.: 21.10.Tg; 23.20.Lv; 27.30.+t.-- Issue title: "ENAM 2004, Fourth International Conference on Exotic Nuclei and Atomic Masses" (Pine Mountain, Georgia, Sep 12-16, 2004). The fast timing βγγ(t) method was applied to investigate the level lifetimes in 30,31,32Mg.
Mach, H., Fraile, Luis M., Tengblad, Olof, Boutami, Rafik, Jollet, C., Plóciennik, W. A., Yordanov, D. T., Stanoiu, M., García Borge, María José, Butler, P. A., Cederkäll, J., Dessagne, Ph., Fogelberg, B., Fynbo, H.O.U., Hoff, P., Jokinen, A., Korgul, A., Köster, Ulli, Kurcewicz, W., Maréchal, F., Motobayashi, T., Mrazek, J., Neyens, G., Nilsson, T., Pedersen, S., Poves, Alfredo, Rubio, Berta, Ruchowska, E.   +27 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Preliminary exploration of metagenomic sequencing for pathogenic identification in infectious uveitis

Journal of Ophthalmic Inflammation and Infection
Purpose To evaluate the advantages and clinical utility of metagenomic sequencing (MGS) in diagnosing infectious uveitis pathogens. Methods A retrospective study was conducted on 20 infectious uveitis patients (20 eyes) who received treatments at the ...
Jinxia Yu, Yane Gao, Hongsheng Bi, Youhua Zhang, Kai Tang, Dadong Guo, Xiaofeng Xie   +6 more
doaj   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source