Results 141 to 150 of about 554,574 (392)

On the role of the transmembrane anchor sequence of influenza hemagglutinin in target cell recognition by class I MHC-restricted, hemagglutinin-specific cytolytic T lymphocytes. [PDF]

, 1987
Thomas J. Braciale, V L Braciale, M. T. C. Winkler, Iwona Stroynowski, Leroy Hood, Joe Sambrook, M J Gething   +6 more
openalex   +1 more source

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Natural polymorphisms in Tap2 influence negative selection and CD4∶CD8 lineage commitment in the rat.

PLoS Genetics, 2014
Genetic variation in the major histocompatibility complex (MHC) affects CD4∶CD8 lineage commitment and MHC expression. However, the contribution of specific genes in this gene-dense region has not yet been resolved.
Jonatan Tuncel, Sabrina Haag, Anthony C Y Yau, Ulrika Norin, Amelie Baud, Erik Lönnblom, Klio Maratou, A Jimmy Ytterberg, Diana Ekman, Soley Thordardottir, Martina Johannesson, Alan Gillett, EURATRANS Consortium, Pernilla Stridh, Maja Jagodic, Tomas Olsson, Alberto Fernández-Teruel, Roman A Zubarev, Richard Mott, Timothy J Aitman, Jonathan Flint, Rikard Holmdahl   +21 more
doaj   +1 more source

Regulation of MHC Class II-Peptide Complex Expression by Ubiquitination

Frontiers in Immunology, 2013
MHC class II (MHC-II) molecules are present on antigen presenting cells (APCs) and these molecules function by binding antigenic peptides and presenting these peptides to antigen-specific CD4+ T cells.
Kyung Jin eCho, Paul A. Roche
doaj   +1 more source

Genetic variation in MHC proteins is associated with T cell receptor expression biases

Nature Genetics, 2016
In each individual, a highly diverse T cell receptor (TCR) repertoire interacts with peptides presented by major histocompatibility complex (MHC) molecules.
Eilon Sharon, L. Sibener, A. Battle, Hunter B. Fraser, K. C. Garcia, Jonathan K. Pritchard   +5 more
semanticscholar   +1 more source

Alloreactive cytotoxic T lymphocytes generated in the presence of viral- derived peptides show exquisite peptide and MHC specificity [PDF]

, 1993
The nature of alloreactivity to MHC molecules has been enigmatic, primarily because of the observation that allogeneic responses are considerably stronger than syngeneic responses. To better determine the specificity potential of allogeneic responses, we
Alexander-Miller, M. A., Burke, K., Connolly, J. M., Hansen, T. H., Koszinowski, Ulrich H.   +4 more
core  

Glucose Deprivation‐Induced Disulfidptosis via the SLC7A11‐INF2 Axis: Pan‐Cancer Prognostic Exploration and Therapeutic Validation

Advanced Science, EarlyView.
Glucose deprivation or GLUT1 inhibition induces disulfidptosis in SLC7A11high ovarian cancer cells by promoting cystine accumulation, NADPH/ATP depletion, and F‐actin disulfide formation. SLC7A11 interacts with INF2 to further increase H₂O₂ levels and impair mitochondrial fission, suppressing cell migration. Targeting the SLC7A11–INF2 axis represents a
Zhenyu Song, Qiuming Yao, Lina Huang, Dan Cui, Jun Xie, Leilei Wu, Jianfeng Huang, Bo Zhai, Dan Liu, Xiao Xu   +9 more
wiley   +1 more source

Locating the second mesiobuccal canal in maxillary molars: challenges and solutions

Clinical, Cosmetic and Investigational Dentistry, 2018
Marcelo Santos Coelho,1 Mariane Floriano Lopes Santos Lacerda,2 Mauro Henrique Chagas Silva,3 Marcos de Azevêdo Rios4 1São Leopoldo Mandic School of Dentistry, Campinas, São Paulo, Brazil; 2Department of Clinical Dentistry, Federal ...
Coelho MS, Lacerda MFLS, Silva MHC, Rios MA   +3 more
doaj  

Salmonella Typhimurium interferes with the humoral immune response in pigs [PDF]

, 2011
Foodborne salmonellosis is one of the most important bacterial zoonotic diseases worldwide. Salmonella Typhimurium is the serovar most frequently isolated from slaughter pigs in Europe.
Boyen, Filip, Flahou, Bram, Haesebrouck, Freddy, Leyman, Bregje, Maes, Dominiek, Pasmans, Frank, Van Parys, Alexander, Verbrugghe, Elin   +7 more
core  

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, EarlyView.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source