Results 331 to 340 of about 556,334 (392)

The ubiquitin-like modifier FAT10 is not essential for MHC-I antigen presentation. [PDF]

Front Immunol
Pach N, Ochs S, Cao J, Ottlinger J, Aichem A, Basler M.   +5 more
europepmc   +1 more source

Optimizing jojoba oil methanolysis of cis‐13‐docosenol fatty alcohol to unveil its immunomodulatory potential: a circular biorefinery perspective

Biofuels, Bioproducts and Biorefining, EarlyView.
Abstract The sustainable production of jojoba oil derivatives depends on research and development focused on eco‐friendly valorization processes. This study establishes optimal conditions for converting jojoba oil into jojobyl alcohols, which is a key step in realizing its economic potential.
Laura Mendoza‐García, Marcos Sánchez, Jorge Mario Marchetti, María Montoya   +3 more
wiley   +1 more source

Single-cell sequencing reveals distinct peripheral immune responses in anti-MDA5 antibody positive dermatomyositis with rapidly progressive interstitial lung disease. [PDF]

Arthritis Res Ther
Weng C, Liu E, Zheng H, Wen Z, Ji Y, Wang G, Zhang L, Hu R, Shen L, Liu Z.   +9 more
europepmc   +1 more source

Revisiting Clonal Evolution Through the Light of Retrotransposons

BioEssays, EarlyView.
We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux, Emilie Elvira‐Matelot, Françoise Porteu, Lucie Laplane   +3 more
wiley   +1 more source

In Vivo Labeling Resolves Distinct Temporal, Spatial, and Functional Properties of Tumor Macrophages and Identifies Subset-Specific Effects of PD-L1 Blockade. [PDF]

Cancer Immunol Res
Lee CYC, Dean I, Richoz N, Li Z, Kennedy BC, Vettore LA, Samarakoon Y, Gilroy KL, Hasegawa T, Carlesso G, Hammond SA, Dovedi SJ, Sansom OJ, Tuong ZK, Halim TYF, Withers DR, Clatworthy MR.   +16 more
europepmc   +1 more source

Production of recombinant methionine‐containing elastin‐like polypeptides in a fermenter using ECPM1 medium

Biotechnology Progress, EarlyView.
Abstract Elastin‐like polypeptides (ELPs) are recombinant protein‐like polymers whose macromolecular structure can be precisely controlled through genetic manipulation of their sequence and length. Their lower critical solution temperature (LCST) phase behavior facilitates purification via chromatography‐free techniques and can be explored for self ...
Alice Delhaes, Laure Bataille, Myriam Médéric, Sébastien Lecommandoux, Elisabeth Garanger   +4 more
wiley   +1 more source

Harnessing chimeric antigen receptor macrophages against solid tumors

Cancer Communications, EarlyView.
Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang, Zhen Qin, Xiu‐Wu Bian, Yu Shi   +3 more
wiley   +1 more source

Sex-Dependent Influence of Major Histocompatibility Complex Diversity on Fitness in a Social Mammal. [PDF]

Mol Ecol
Schubert N, Nichols HJ, Mwanguhya F, Businge R, Kyambulima S, Mwesige K, Hoffman JI, Cant MA, Winternitz JC.   +8 more
europepmc   +1 more source

Lactylation in cancer biology: Unlocking new avenues for research and therapy

Cancer Communications, EarlyView.
Abstract Lactylation, a newly identified post‐translational modification, plays a multifaceted role in cancer biology by integrating epigenetic and non‐epigenetic mechanisms. This review summarizes the latest research progress on lactylation, including its functions in epigenetic regulation and its broader impact on cellular processes.
Xiaoyu Hou, Zhenya Hong, Huimin Zeng, Changyi Zhang, Peng Zhang, Ding Ma, Zhiqiang Han   +6 more
wiley   +1 more source