Results 341 to 350 of about 556,334 (392)
Mechanism and role of regulated cell death in tumor immunity and immunotherapy
Cancer Communications, EarlyView.Abstract Cancer immune checkpoint inhibitors (ICIs) have brought breakthroughs, but only about one‐third of cancer patients benefit from ICIs. In recent years, targeting non‐apoptotic regulated cell death (RCD) subtypes, such as ferroptosis, necroptosis, autophagy, cuproptosis, and pyroptosis, has emerged as a novel strategy in cancer therapy due to ...
Jingwen Hu +4 more
wiley +1 more source
Breaking barriers: the cGAS‐STING pathway as a novel frontier in cancer immunotherapy
Cancer Communications, EarlyView.Abstract Since its discovery, the cyclic GMP‐AMP synthase (cGAS)‐stimulator of the interferon gene (STING) signaling pathway has been considered a pivotal component of innate immunity and a promising target for cancer immunotherapy. Beyond its canonical role in pathogen defense, accumulating evidence has demonstrated that the cGAS‐STING pathway ...
Yuheng Yan +5 more
wiley +1 more source
ChemistryEurope, EarlyView.Nitration of glycolipids and phospholipids increases their binding to CD1d. Nitrated β‐GlcCer and phospholipids show strong CD1d binding but induce minimal cytokine production, suggesting potential immune suppression. In contrast, nitrated endogenous‐type α‐GalCer enhances cytokine responses, indicating that nitrated lipids can modulate CD1d‐mediated ...
Kodai Sueyoshi +5 more
wiley +1 more source
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Current Opinion in Immunology, 1993
In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptides that induce autoimmune disease ...
Milner, Caroline, Campbell, R. Duncan
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In the last year progress has been made towards elucidating the roles of the MHC gene products in autoimmunity. A major advance has been the recent determination of the crystallographic structure of the human MHC class II molecule, which will be invaluable in delineating the minimum structural requirements for peptides that induce autoimmune disease ...
Milner, Caroline, Campbell, R. Duncan
openaire +4 more sources
MHC polymorphism and parasites
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1994The major histocompatibility complex (MHC) polymorphism is marked by the existence of allelic lineages that are extremely old, having been passed from one species to another in an evolutionary line of descent. Each species has several of these lineages and many of their more recent derivatives, the actual alleles.
Colm O'hUigin, Jan Klein
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MHC-NP: Predicting peptides naturally processed by the MHC
Journal of Immunological Methods, 2013We present MHC-NP, a tool for predicting peptides naturally processed by the MHC pathway. The method was part of the 2nd Machine Learning Competition in Immunology and yielded state-of-the-art accuracy for the prediction of peptides eluted from human HLA-A*02:01, HLA-B*07:02, HLA-B*35:01, HLA-B*44:03, HLA-B*53:01, HLA-B*57:01 and mouse H2-D(b) and H2-K(
Mario Marchand +5 more
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Odortypes and MHC peptides: complementary chemosignals of MHC haplotype?
Trends in Neurosciences, 2006The olfactory and immune systems must perform optimally in the task of recognizing thousands of molecules to ensure survival. A particularly intriguing link between these systems is that animals can smell differences in the major histocompatibility complex (MHC), a cluster of highly polymorphic genes found on human chromosome 6 and mouse chromosome 17.
Gary K. Beauchamp +4 more
openaire +3 more sources