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MHC-associated and MHC-independent urinary chemosignals in mice
Physiology & Behavior, 1996The chemosensory identity of mice, rats, and humans is determined partly by polymorphic genes of the major histocompatibility complex (MHC). In inbred strains of mice as well as in seminatural populations MHC-associated mating preferences selectively influence reproductive success.
Carsten Höller +4 more
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MHC and MHC‐related proteins as pleiotropic signal molecules
The FASEB Journal, 2002Class I molecules of the major histocompatibility complex (MHC) have been studied primarily for their role in presenting peptide antigens to conventional T lymphocytes. An increasing body of evidence suggests that MHC and newly characterized MHC-related molecules have a much more varied function in the body.
Gabriel Gachelin +3 more
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Immunology Today, 1995
Abstract The major histocompatibility complex (MHC) has been studied for many years, but it still continues to puzzle geneticists and immunologists alike. Nevertheless, the study of MHC evolution is providing insights into some of its enigmas, and these were discussed at a recent meeting.
DanielE. Geraghty, StephenH. Powis
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Abstract The major histocompatibility complex (MHC) has been studied for many years, but it still continues to puzzle geneticists and immunologists alike. Nevertheless, the study of MHC evolution is providing insights into some of its enigmas, and these were discussed at a recent meeting.
DanielE. Geraghty, StephenH. Powis
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Genetica, 1998
The MHC is highly polymorphic in most vertebrates and the suggested selective mechanisms responsible for the maintenance of this variation are several, including maternal-fetal interaction, parasite resistance, and negative-assortative mating. Evidence for these mechanisms is reviewed and estimates of the amount of selection in a number of studies are ...
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The MHC is highly polymorphic in most vertebrates and the suggested selective mechanisms responsible for the maintenance of this variation are several, including maternal-fetal interaction, parasite resistance, and negative-assortative mating. Evidence for these mechanisms is reviewed and estimates of the amount of selection in a number of studies are ...
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Immunological Reviews, 1999
Summary: The human Major Histocompatibility Complex (MHC) shares similarities with three other chromosome regions in human. This could be the vestige of ancestral large scale duplications. We discuss here the possibility i) that these duplications occurred during two rounds of tetraploidization supposed to have taken place during chordate evolution ...
Michael F. McDermott +2 more
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Summary: The human Major Histocompatibility Complex (MHC) shares similarities with three other chromosome regions in human. This could be the vestige of ancestral large scale duplications. We discuss here the possibility i) that these duplications occurred during two rounds of tetraploidization supposed to have taken place during chordate evolution ...
Michael F. McDermott +2 more
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Science Signaling, 2011
Major histocompatibility class II molecules promote Toll-like receptor signaling in macrophages and dendritic cells.
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Major histocompatibility class II molecules promote Toll-like receptor signaling in macrophages and dendritic cells.
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Evolutionary Anthropology: Issues, News, and Reviews, 2005
The major histocompatibility complex (MHC) contains the most diverse genes known in vertebrates. These genes encode cell-surface molecules that play a central role in controlling immunological activity and, as a consequence, in tissue rejection, autoimmunity, and immune responses to infectious diseases.
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The major histocompatibility complex (MHC) contains the most diverse genes known in vertebrates. These genes encode cell-surface molecules that play a central role in controlling immunological activity and, as a consequence, in tissue rejection, autoimmunity, and immune responses to infectious diseases.
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Current Opinion in Immunology, 2004
The MHC, primarily known for its antigen-presenting class I and II molecules, harbours, within a central segment of less than 1 Mb, a dense collection of genes involved in various biological functions. Although MHC I and MHC II are principal players of adaptive immunity, several loci within this central (still called class III) MHC region encode ...
Seiamak Bahram, Georges Hauptmann
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The MHC, primarily known for its antigen-presenting class I and II molecules, harbours, within a central segment of less than 1 Mb, a dense collection of genes involved in various biological functions. Although MHC I and MHC II are principal players of adaptive immunity, several loci within this central (still called class III) MHC region encode ...
Seiamak Bahram, Georges Hauptmann
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The discovery of MHC restriction
Immunology Today, 1997Abstract The chance discovery 20 years ago that virus-specific cytotoxic T lymphocytes recognized antigen together with major histocompatibility complex (MHC) class I glycoproteins was the key to understanding immune surveillance of self. The altered-self hypothesis biological basis for alloreactivity.
Peter C. Doherty, Rolf M. Zinkernagel
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Trends in Immunology, 2005
In animals, it is the female that typically selects a mating partner. This decision can occur before, during and after copulation. Here, recent evidence for the involvement of genes within the MHC in female choice is reviewed and the roles of MHC I and II antigens, various types of chemoreceptors, as well as MHC-encoded transcription factors, in ...
Andreas Ziegler +2 more
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In animals, it is the female that typically selects a mating partner. This decision can occur before, during and after copulation. Here, recent evidence for the involvement of genes within the MHC in female choice is reviewed and the roles of MHC I and II antigens, various types of chemoreceptors, as well as MHC-encoded transcription factors, in ...
Andreas Ziegler +2 more
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