Results 311 to 320 of about 253,649 (335)
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Mutation of RFXAP, a Regulator of MHC Class II Genes, in Primary MHC Class II Deficiency
New England Journal of Medicine, 1997Major-histocompatibility-complex (MHC) class II deficiency is an autosomal recessive primary immunodeficiency disease in which MHC class II molecules are absent. It is a genetically heterogeneous disease of gene regulation resulting from defects in several transactivating genes that regulate the expression of MHC class II genes.
Villard, Jean +5 more
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Identification of MHC Class II Binding Peptides: Microarray and Soluble MHC Class II Molecules
2009CD4+ T-helper cells recognize antigenic peptides presented by MHC class II molecules. The binding of the nominal peptide to the MHC class II allele is dependent on the amino acid sequence of the peptide as well as on amino acid (aa) residues in the peptide binding groove of the MHC class II allele.
Simani, Gaseitsiwe, Markus J, Maeurer
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Regulation of MHC class II gene expression by the class II transactivator
Nature Reviews Immunology, 2005MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern.
Reith, Walter +2 more
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Class II MHC typing in pemphigoid gestationis
Clinical and Experimental Dermatology, 1995Pemphigoid gestationis (PG) is a rare, autoimmune skin disease associated with pregnancy or the immediate post-partum period, previously shown to be associated with the HLA class II antigens DR3 and DR4. Advances in molecular analytical techniques now allow the identification of HLA alleles previously difficult to define by serological assays ...
J K, Shornick +7 more
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Biochemistry of MHC class II molecules
Tissue Antigens, 1985R C, Giles, J D, Capra
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MHC class II expression by the gut epithelium
Immunology Today, 1988Abstract The intestinal epithelium represents a barrier between luminal antigen and the underlying local immune system. Expression of MHC class II antigens — normally associated with cells of defined immunological function — and the alteration in the pattern of expression of these antigens found in certain diseases, has aroused considerable interest ...
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The evolution of MHC class II genes
Immunology Today, 1986F, Figueroa, J, Klein
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