Results 111 to 120 of about 701,149 (346)

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, EarlyView.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources

A Preliminary Assessment of Yellow Pigment from Streptomyces parvulus C5-5Y

Journal of Pure and Applied Microbiology, 2017
A yellow pigment producing potent strain Streptomyces parvulus C5-5Y (KJ624998) isolated from leather industry was used in this study. The pigmented metabolite exhibited good spectrum of antagonistic activity against common human clinical pathogens ...
A. Parimala Gnana Soundari, V. Manon Mani, V. Subhash Chandra Bose, J. Jabastin, V. Brindha Priyadarisini   +4 more
doaj   +1 more source

Fmps On Mic

, 2014
The Finite Element Method software system FMPS is briefly introduced and an overview is given of development work done by HLRS and VSB concerning the acceleration of solutions to problems yielded by FMPS using Intel’s Many Integrated Core architecture. HLRS implemented a hybrid MPI/OpenMP Conjugate Gradient solver.
openaire   +2 more sources

High‐Throughput Tiling of Essential mRNAs Increases Potency of Antisense Antibiotics

Advanced Science, EarlyView.
The systematic tiling of essential genes’ mRNA here presented, proposes a valuable tool for the identification of novel PNA sequences with antibiotic potential. The high‐throughput synthetic set up opens the door to investigating thousands of sequences in an economic way and ultimately identifies potent antisense oligonucleotides while also giving room
Giorgia Danti, Linda Popella, Jörg Vogel, Hans M. Maric   +3 more
wiley   +1 more source

Saarvienin A—A Novel Glycopeptide with Potent Activity against Drug‐Resistant Bacteria

Angewandte Chemie, EarlyView.
A structurally distinct glycopeptide, saarvienin A, represents a new family of glycopeptide antibiotics consisting of five sugar/aminosugar units connected to a halogenated peptide core. Saarvienin A overcomes vancomycin resistance and shows strong activity against drug‐resistant Gram‐positive bacteria, in particular, high‐priority pathogens such as ...
Amninder Kaur, Jaime Felipe Guerrero‐Garzón, Sari Rasheed, Martin Zehl, Franziska Fries, Bernd Morgenstern, Sergey B. Zotchev, Rolf Müller   +7 more
wiley   +2 more sources

Isolation of a Novel Antimicrobial Compounds Producing Fungus Aspergillus niger MTCC 12676 and Evaluation of its Antimicrobial Activity against Selected Pathogenic Microorganisms

Journal of Pure and Applied Microbiology, 2017
A novel antimicrobial compounds producing strain of fungus was isolated from rhizospheric soil and identified as Aspergillus niger MTCC 12676 on the basis of morphological characters and molecular identification. Antimicrobial activity of this strain was
Amrinder Singh, Mukesh Kumar, Raj Kumar Salar   +2 more
doaj   +1 more source

Equitability Analysis of the Maximal Information Coefficient, with Comparisons [PDF]

arXiv, 2013
A measure of dependence is said to be equitable if it gives similar scores to equally noisy relationships of different types. Equitability is important in data exploration when the goal is to identify a relatively small set of strongest associations within a dataset as opposed to finding as many non-zero associations as possible, which often are too ...
arxiv  

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

An excess of mid-IR luminous galaxies in Abell 1689? [PDF]

arXiv, 2000
We present the results of infrared observations of Abell 1689 which was observed with ISOCAM, at 6.7\mic and 15\mic, and ISOPHOT at 200\mic. The cluster galaxies detected above a sensitivity limit of 0.15 mJy in the 6.7\mic band, whose emission is mostly dominated by their stellar component, show optical colors similar to the overall cluster population
arxiv  

Is China Systematically Buying Up Key Technologies? Chinese M & A transactions in Germany in the context of “Made in China 2025”. Bertelsmann Stiftung GED Study 2018 [PDF]

, 2018
“Made in China 2025” (MIC 2025) is the Chinese central government’s main industrial policy strategy aimed at turning China into the global leader of the fourth industrial revolution.
Jungbluth, Cora
core