Results 251 to 260 of about 701,149 (346)

Isoniazid‐Dihydropyrimidinone Molecular Hybrids: Design, Synthesis, Antitubercular Activity, and Cytotoxicity Investigations with Computational Validation

ChemMedChem, EarlyView.
Antitubercular evaluation of a novel library of isoniazid‐dihydropyrimidinone molecular hybrids (8a–8n) discloses a potent compound with MIC = 0.39μg mL−1 against M. tuberculosis mc26230. Cytotoxicity, stability, and in silico studies, including molecular docking and ADME/T (absorption, distribution, metabolism, excretion, and toxicity) analysis ...
Gobind Kumar, Pule Seboletswe, Sahil Mishra, Neha Manhas, Safiyah Ghumran, Nagaraju Kerru, Françoise Roquet‐Banères, Maëlle Foubert, Laurent Kremer, Gaurav Bhargava, Parvesh Singh   +10 more
wiley   +1 more source

Differences in the Clinicopathologic and Radiological Characteristics of Patients With Microcystic and Macrocystic Serous Cystadenoma of the Pancreas. [PDF]

Pancreas
Lu X, Dai Y, Liu X, Jiang L, Zhang K, Wu J, Gao W, Jiang K, Dai C, Miao Y, Li M, Wei J.   +11 more
europepmc   +1 more source

Green’s function for the five-dimensional SU(2) MIC–Kepler problem [PDF]

, 2000
Mikhail Pletyukhov, E. A. Tolkachev
openalex   +1 more source

Quinoline ATP Synthase Inhibitors with Activity Against Multidrug Resistant Acinetobacter baumannii and Pseudomonas aeruginosa

ChemMedChem, EarlyView.
Targeting ATP synthase in Gram‐negative pathogens. Presented is the first disclosure of quinoline‐derived antibiotics inhibiting multidrug resistant Acinetobacter baumannii ATP synthase and expansion of the structure activity relationship profile of Pseudomonas aeruginosa ATP synthase inhibitors.
Katie T. Ward, Alexander P. L. Williams, Angelina L. Dennison, Lena Aamir, Darien L. Allen, Britza Chavez‐Arellano, Toni A. Marchlewski, Mars L. Zappia, Amanda L. Wolfe, P. Ryan Steed   +9 more
wiley   +1 more source

Trends of Colistin MIC Among <i>Acinetobacter Baumannii</i> and <i>Pseudomonas aeruginosa</i> at a First-Class Hospital in Vietnam. [PDF]

J Trop Med
Nguyen THN, Nguyen HQ, Le NTT, Nguyen HTN, Dinh HC, Nguyen TN, Nguyen HM.   +6 more
europepmc   +1 more source

New species-related MIC breakpoints for early detection of development of resistance among Gram-negative bacteria in Swedish intensive care units

, 1999
Håkan Hanberger, Lennart E. Nilsson, Berndt E. B. Claesson, Anders Kärnell, Peter Larsson, M Rylander, Erik Svensson, Mikael Sörberg, L. Sörén   +8 more
openalex   +1 more source

You do what?! - You had better show me [PDF]

, 2004
Porter, Mic
core  

Is Mycobacterial InhA a Suitable Target for Rational Drug Design?

ChemMedChem, EarlyView.
InhA is the target of isoniazid, a first‐line antituberculosis drug. Isoniazid is, in fact, a prodrug that needs to be activated. Researchers are trying to develop direct inhibitors of InhA. This includes the resolution of crystallographic structures. The Protein Data Bank contains over a hundred InhA structures.
Julien Rizet, Laurent Maveyraud, David Rengel, Valérie Guillet, Gabriel Publicola, Frédéric Rodriguez, Christian Lherbet, Lionel Mourey   +7 more
wiley   +1 more source

Healthcare-associated bloodstream infections caused by bacterial and fungal contamination of intravenous fluids and medicines in healthcare facilities in low- and middle-income countries: a scoping review. [PDF]

Antimicrob Resist Infect Control
Nyandwaro J, Hyland P, Ravinetto R, Jacobs J.   +3 more
europepmc   +1 more source

Novel quinazolinones active against multidrug‐resistant Mycobacterium tuberculosis: synthesis, antimicrobial evaluation and in silico exploration of PonA1 as a potential target

ChemMedChem, Accepted Article.
Quinazolinone derivatives have emerged as promising scaffolds in antimicrobial drug discovery. This work focuses on the design, synthesis, and evaluation of novel quinazolinone‐based compounds and predicts their potential to interact with mycobacterial penicillin‐binding proteins (PBPs).
MAREK KERDA, Daria Nawrot, Petr Slechta, Mirek Domanský, Asal Askari, Hanieh Kamangar, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Ingrid Hlbočanová, Miloslav Macháček, Matteo Mori, Fiorella Meneghetti, Martin Doležal, Jan Zitko, Ghada Bouz   +15 more
wiley   +1 more source