Results 121 to 130 of about 502,511 (394)

MICA-129 Dimorphism and Soluble MICA Are Associated With the Progression of Multiple Myeloma

Frontiers in Immunology, 2018
Natural killer (NK) cells are immune innate effectors playing a pivotal role in the immunosurveillance of multiple myeloma (MM) since they are able to directly recognize and kill MM cells. In this regard, among activating receptors expressed by NK cells,
A. Zingoni, E. Vulpis, Francesca Cecere, M. Amendola, D. Fuerst, Taron Saribekyan, A. Achour, T. Sandalova, Ilaria Nardone, Agnese Peri, A. Soriani, C. Fionda, Elena Mariggiò, M. Petrucci, M. R. Ricciardi, J. Mytilineos, M. Cippitelli, C. Cerboni, A. Santoni   +18 more
semanticscholar   +1 more source

CRISPR/Cas13a: Compensatory Target Activation Mechanism

Advanced Science, EarlyView.
CRISPR/Cas13a‐CTAM as a novel compensatory target activation mechanism that enables synergistic activation of Cas13a via two independently editable short RNA effectors. This dual‐effector system maintains enzymatic activity comparable to traditional single‐effector while significantly enhancing flexibility, sensitivity, and application scope.
Bowen Jiang, Tenghua Zhang, Yao Lu, Shujun Zhou, Wenjing Xiao, Shuming Pan, Nan Shi, Yan Sheng, Jiaming Hu   +8 more
wiley   +1 more source

Conteúdo estomacal da palombeta-do-caribe Brama caribbea (Mead, 1972), proveniente do conteúdo estomacal de grandes predadores pelágicos do atlí­¢ntico sudoeste equatorial

Boletim do Instituto de Pesca, 2018
A palombeta-do-caribe, Brama caribbea, é um item alimentar comum em grandes predadores no Atlí­¢ntico sudoeste equatorial. Conteúdos estomacais de 185 exemplares de B.
Teodoro Vaske Júnior, Rosângela Paula Lessa, Taciana Martins Barbosa, Mariana Travassos Tolotti, Aurelyanna Christine Bezerra Ribeiro   +4 more
doaj  

Rhizome de l’écosystème du numérique universitaire français et nouvelle gouvernance : Mutualisation, gouvernance et numérique universitaire

Médiations & Médiatisations
Nous proposons de caractériser l’organisation du numérique universitaire français, en examinant ses processus de fabrication, de fonctionnement et de gouvernance en interrogeant le concept de rhizome, développé en 1980 par Deleuze et Guattari.
Bertrand Mocquet
doaj   +1 more source

Mineralogia e reserva de K de Cambissolos submetidos a diferentes manejos após derrubada e queima da floresta na Amazônia Meridional Mineralogy and K reserve of Cambisols submitted to different managements after slashing and burning of the forest in the Meridional Amazon, Brazil

Acta Amazonica, 2012
As altas temperaturas ocorrentes durante a queima na floresta Amazônica podem induzir transformações mineralógicas da fração argila. Este trabalho objetivou avaliar as alterações mineralógicas nas frações areia, silte e argila e na reserva mineral de ...
Alessandro Góis Orrutéa, Vander de Freitas Melo, Antônio Carlos Vargas Motta, Valmiqui Costa Lima   +3 more
doaj   +1 more source

Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound

Advanced Science, EarlyView.
Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García, José A. Pineda‐Pardo, Inés Trigo‐Damas, Marta Gutiérrez, Marta Castillo‐Ortiz, Megan Carrillo, Alejandro Reinares‐Sebastian, Víctor Medina‐Chavarrías, Itay Rachmilevitch, Masahiko Takada, José A. Obeso, Javier Blesa   +11 more
wiley   +1 more source

Review for "Associations of high‐resolution‐typing‐defined MICA and MICB polymorphisms, and the levels of soluble MICA and MICB with Oral Squamous Cell Carcinoma in Bulgarian patients"

, 2021

openalex   +1 more source

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Resveratrol promotes MICA/B expression and natural killer cell lysis of breast cancer cells by suppressing c-Myc/miR-17 pathway

OncoTarget, 2017
Major histocompatibility complex class I chain-related proteins A and B (MICA and MICB) are important ligands for recognition of tumor cells by immune effector cells.
Jie Pan, Jiaying Shen, Wengong Si, C. Du, Danni Chen, Liang Xu, Minya Yao, P. Fu, W. Fan   +8 more
semanticscholar   +1 more source

Optimization of SWCNT‐FET Biosensors by Aptamer Engineering and Toehold‐Mediated Strand Displacement

Advanced Science, EarlyView.
Aptamer‐based single‐walled carbon nanotube (SWCNT) field‐effect transistor (FET) biosensors are developed for label‐free, real‐time biomarker detection. Truncated DNA aptamers enhance sensitivity through improved conformational switching. A toehold‐mediated strand displacement (TMSD) strategy optimizes functionalization and simplifies fabrication. The
Haosen Miao, Tingting Zheng, Houlin Yu, Gririraj Manoharan, Gustavo Sant'Anna, Nicholas Bedfrod, Jorge L. Chávez, Chang‐Seuk Lee, Matteo Palma   +8 more
wiley   +1 more source