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Micafungin: A New Echinocandin Antifungal
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 2007The echinocandins represent the newest class of antifungals to combat infections caused by Candida sp. Micafungin is an echinocandin recently approved by the United States Food and Drug Administration. It is indicated in adults for esophageal candidiasis and prophylaxis against candidal infections in hematopoietic stem cell transplant recipients ...
Jomy M. Joseph +2 more
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Micafungin and a case of polymorphic ventricular tachycardia
Journal of Clinical Pharmacy and Therapeutics, 2016Although echinocandins are relatively safe antifungal drugs, cardiovascular toxicity is an emerging adverse event. This report reviews those side effects and describes a case of polymorphic ventricular tachycardia suggestive of torsades de pointes with micafungin.The patient was on micafungin for oesophageal candidiasis due to drug-drug interactions ...
P. J. Shah +3 more
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Safety of Micafungin in Pediatric Clinical Trials
Pediatric Infectious Disease Journal, 2011Pediatric patients with invasive fungal infections are often fragile hosts with multiple underlying conditions. Safety is an important feature of antifungal agents to be used in this setting. This study aims to evaluate safety of micafungin in pediatric patients (
Antonio Arrieta +2 more
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Acute Pancreatitis in a Patient Treated with Micafungin
Clinical Therapeutics, 2007A 73-year-old man (height, 158.2 cm; weight, 49.8 kg) presented with upper abdominal tenderness after 3 weeks of treatment with 150 mg/d of micafungin (3 mg/kg . d) (Mycamine, Astellas Pharma US Inc., Deerfield, Illinois) intravenously for pulmonary aspergillosis accompanied by [DOSAGE ERROR CORRECTED] pulmonary Mycobacterium avium complex (MAC ...
Masatomo Mori +5 more
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Effects of micafungin on the morphology of Aspergillus fumigatus
Journal of Electron Microscopy, 2005The morphological effects of micafungin, a member of a new class of antifungal agents candins, on growing hyphae of Aspergillus fumigatus were studied by the use of Nomarski microscopy, scanning electron microscopy and thin-section electron microscopy.
Yayoi Nishiyama +4 more
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Micafungin-induced immune hemolysis attacks
International Journal of Hematology, 2009The echinocandins provide an attractive new option for prophylactic and empirical treatment of invasive fungal infections in patients with neutropenia after intensive cytotoxic chemotherapy or hematopoietic stem cell transplantation. We present two patients with hematological diseases who experienced massive intravascular hemolysis followed by renal ...
Norio Asou +6 more
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Population pharmacokinetics of micafungin in adult patients
Diagnostic Microbiology and Infectious Disease, 2008We performed population pharmacokinetic analysis of micafungin in adult patients treated with doses between 12.5 and 200 mg/day. Our analysis identified a breakpoint patient weight of 66.3 kg above which serum clearance increased by approximately 50%. Patients with weight >66.3 kg may need larger doses to achieve similar exposures to those
Donald N. Buell +5 more
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Optimizing Micafungin Dosing in Children
Pediatric Infectious Disease Journal, 2012Wei Zhao +3 more
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Efficacy of micafungin for the treatment of candidemia
European Journal of Clinical Microbiology & Infectious Diseases, 2005Nasia Safdar, David R. Andes
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