Results 261 to 270 of about 5,339,934 (354)

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source

Constitutively Active Stat5b Expression in Dendritic Cells Enhances Treg-Mediated Elimination of Autoreactive CD8⁺ T Cells in Autoimmune Diabetes. [PDF]

Int J Mol Sci
Khongorzul P, Khan FU, Levasseur D, Gris D, Amrani A.   +4 more
europepmc   +1 more source

VPS4A is the selective receptor for lipophagy in mice and humans

Debajyoti Das, Mridul Sharma, Deepanshi Gahlot, Shervin S Nia, Chandrima Gain, Matthew Mecklenburg, Z. Hong Zhou, Mathieu Bourdenx, Lipi Thukral, Nuria Martínez-López, Rajat Singh   +10 more
openalex   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

Benznidazole therapy improves pressure overload and cardiac electrical profile in an experimental model of Angiotensin II infusion-induced hypertension: Mechanistic insights. [PDF]

PLoS One
da Silva Pinheiro P, Vilar-Pereira G, Castaño-Barrios L, Peroba Rezende Ramos I, Pedra-Rezende Y, Dantas-Pereira L, Figueiredo Sadok Menna-Barreto R, Gibaldi D, Mata-Santos HA, Lannes-Vieira J.   +9 more
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

ELK1 promotes the progress of myeloid leukemia by hindering the differentiation of neutrophils. [PDF]

Exp Hematol Oncol
He Y, Zhou Y, Wen D, Guo R, Du J, Huang S, Dong Y.   +6 more
europepmc   +1 more source

Astrocyte-derived lactoferrin inhibits neuronal ferroptosis by reducing iron content and GPX4 degradation in APP/PS1 transgenic mice

Yonggang Fan, Ri‐Le Ge, Hang Ren, Rong‐Jun Jia, Ting-Yao Wu, Xian-Fang Lei, Zheng Wu, Xiao-Bei Zhou, Zhan‐You Wang   +8 more
openalex   +1 more source