Results 261 to 270 of about 6,887,725 (399)

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus. [PDF]

Nat Commun
Tao L, Teng L, Ge M, Wang Y, Hu C, Chen J, Zhao J, Cheng L, Zhang Z, Qin W, Jia Y, Mi D, Yuan Z, Chen L.   +13 more
europepmc   +1 more source

Continuous Activation of Renin-Angiotensin System Impairs Cognitive Function in Renin/Angiotensinogen Transgenic Mice [PDF]

, 2008
Shinji Inaba, Masaru Iwai, Megumi Furuno, Yumiko Tomono, Harumi Kan‐no, Izumi Senba, Hideki Okayama, Masaki Mogi, Jitsuo Higaki, Masatsugu Horiuchi   +9 more
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Sleep fragmentation exacerbates myocardial ischemia-reperfusion injury via hypothalamic paraventricular nucleus-resident OX1R-mediated sympathetic hyperactivity in adult mice. [PDF]

Ann Med
Zhu X, Guo L, Chen N, Wang L, Dai S, Liu X, Chen X, Wang C, Cao Y, Hu H, Wang E.   +10 more
europepmc   +1 more source

Postnatal microbial colonization programs the hypothalamic–pituitary–adrenal system for stress response in mice

Journal of Physiology, 2004
N. Sudo, Y. Chida, Y. Aiba, J. Sonoda, Naomi Oyama, Xiao-Nian Yu, C. Kubo, Y. Koga   +7 more
semanticscholar   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

FEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani, Hiroya Ueda, Ayumi Kawata, Yuki Sato, Kotomi Inomata, Hiroshi Mano, Masahiro Wada, Kenji Kobata   +7 more
wiley   +1 more source

TRPV2 in muscle satellite cells is crucial for skeletal muscle remodelling. [PDF]

Cell Death Dis
Chen Y, Katanosaka K, Shibuya M, Dong Y, Zhang L, Kanagawa M, Fukada SI, Naruse K, Katanosaka Y.   +8 more
europepmc   +1 more source

Different immune cells mediate mechanical pain hypersensitivity in male and female mice

Nature Neuroscience, 2015
R. Sorge, Josiane C. S. Mapplebeck, S. Rosen, S. Beggs, Sarah R. Taves, Jessica K. Alexander, Loren J. Martin, J. Austin, S. Sotocinal, Di Chen, Mu Yang, X. Shi, Hao Huang, Nicolas J. Pillon, P. Bilan, YuShan Tu, A. Klip, R. Ji, Ji Zhang, M. Salter, J. Mogil   +20 more
semanticscholar   +1 more source

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

FEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito, Masashi Arakawa, Koki Maeda, Eiji Morita   +3 more
wiley   +1 more source