Results 321 to 330 of about 4,155,608 (362)

Erqember Mitigates Neurotoxic Effects of Aluminum Chloride in Mice: Phytochemical Insights With Neurobehavioral and In Silico Approaches. [PDF]

J Toxicol
Khan H, Javaid S, Ashraf W, Siddique F, Bibi M, Ahmad T, Gill MSA, Abrar A, Alqahtani F, Imran I.   +9 more
europepmc   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Renal Tubule-Specific Angiotensinogen Deletion Attenuates SGLT2 Expression and Ameliorates Diabetic Kidney Disease in Murine Models of Type 1 Diabetes. [PDF]

Diabetes
Yang WX, Su K, Liao MC, Zhou J, Peng J, Hébert MJ, Leal DN, Yamashita M, Miyata KN, Filep JG, Ingelfinger JR, Zhang SL, Chan JSD.   +12 more
europepmc   +1 more source

RhoA and Rac1 as Mechanotransduction Mediators in Colorectal Cancer

Advanced Biology, EarlyView.
Analysing RhoA and Rac1 protein levels in Colorectal cancer (CRC) samples under mechanical strain highlights their potential as diagnostic markers. Monitoring their activity could offer valuable insights into how cancer spreads, paving the way for new approaches to better understand and diagnose colorectal cancer.
Sharda Yadav, Sanjaya KC, Mark A. T. Blaskovich, Cu‐tai Lu, Alfred K Lam, Nam‐Trung Nguyen   +5 more
wiley   +1 more source

Proteome Size Is Positively Correlated with Lifespan in Mammals but Negatively Correlated with Lifespan in Birds

Advanced Biology, EarlyView.
The relationship between proteome size, amino acid composition, and lifespan across 276 vertebrate species is investigated. Proteome size correlates positively with lifespan in mammals but negatively in birds and fish. While proteome composition varies among classes, no single amino acid frequency correlates with lifespan.
Juliano Morimoto, Zuzanna Pietras
wiley   +1 more source

Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice. [PDF]

Cell Commun Signal
Liu DH, Li F, Yang RZ, Wu Z, Meng XY, Li SM, Li WX, Li JK, Wang DD, Wang RY, Li SA, Liu PP, Kang JS.   +12 more
europepmc   +1 more source

Scaling Up Synthetic Cell Production Using Robotics and Machine Learning Toward Therapeutic Applications

Advanced Biology, EarlyView.
Synthetic cells (SCs) hold great promise for biomedical applications, but manual production limits scalability. This study presents an automated method for large‐scale SC synthesis, integrating robotic liquid handling and machine learning‐driven high‐throughput characterization.
Noga Sharf‐Pauker, Ido Galil, Omer Kfir, Gal Chen, Rotem Menachem, Jeny Shklover, Avi Schroeder, Shanny Ackerman   +7 more
wiley   +1 more source

A Common <i>UDP-Glucuronosyltransferase</i> (<i>UGT</i>)<i>1A</i> Haplotype Is Associated With Accelerated Aging in Humanized Transgenic Mice. [PDF]

Oxid Med Cell Longev
Langhans B, Strassburg CP, Röcken C, Kalthoff S.   +3 more
europepmc   +1 more source

Repeated activation of preoptic area recipient neurons in posterior paraventricular nucleus mediates chronic heat-induced negative emotional valence and hyperarousal states. [PDF]

Elife
Cao Z, Yung WH, Ke Y.
europepmc   +1 more source

Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice. [PDF]

Cell Death Dis
Wang YH, Zhou N, Wan PP, Li XT, Yu CY, Chou J, Feng ZY, Zhang LX, Li JJ, Yu BC, Tang ZN, Liu KM, Guo L.   +12 more
europepmc   +1 more source