Results 41 to 50 of about 4,772,082 (338)
The individuality of mice [PDF]
Genes, Brain and Behavior, 2004 Mutant mice simulating human CNS disorders are used as models for therapeutic drug development. Drug evaluation requires a coherent correlation between behavioral phenotype and drug status. Variations in behavioral responses could mask such correlations, a problem highlighted by the three‐site studies ofCrabbeet al. (1999) andWahlstenet al.
openaire +3 more sources
Pharmacological Research, 2023 Specific medications to combat cerebellar ataxias, a group of debilitating movement disorders characterized by difficulty with walking, balance and coordination, are still lacking.
Shu-Tao Xie +18 more
doaj
Economies, 2021 We evaluated the movement in the daily number of COVID-19 cases in response to the real GDP during the COVID-19 pandemic in Thailand from Q1 2020 to Q1 2021. The aim of the study was to find the number of COVID-19 cases that could maintain circulation of
Chanamart Intapan +2 more
doaj +1 more source
Klotho mice: a novel wound model of aged skin. [PDF]
, 2014 BackgroundAs the elderly population continues to expand, it becomes increasingly important to develop treatments to improve wound healing in the elderly.
Yamashita, Ken +3 more
core +2 more sources
A vaccine formulated with the major outer membrane protein can protect C3H/HeN, a highly susceptible strain of mice, from a Chlamydia muridarum genital challenge. [PDF]
, 2015 C3H/HeN female mice were vaccinated with native Chlamydia muridarum major outer membrane protein (MOMP), using Montanide+CpG or Alum+CpG as adjuvants. Negative control groups were immunized with ovalbumin (OVA) and the same adjuvants. As positive control,
de la Maza, Luis M +2 more
core +1 more source
Proceedings of the National Academy of Sciences, 2014 A vibrant discussion of the merits and limitations of animal models is long overdue. The limitation of space precludes addressing many of the questionable approaches and statements by Takao and Miyakawa (1).
Ronald W. Davis +8 more
openaire +3 more sources
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Npp1 promotes atherosclerosis in ApoE knockout mice. [PDF]
, 2011 Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1) generates inorganic pyrophosphate (PP(i)), a physiologic inhibitor of hydroxyapatite deposition.
Nitschke, Yvonne +3 more
core +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
GEOmedia, 2006 In una regione afflitta da molte problematiche legate alla gestione del territorio, il Comune di Rogliano in provincia di Cosenza (Calabria) ha intrapreso una strada di innovazione e di efficienza, dotandosi di un S.I.T.
Vittorio Gagliardi +3 more
doaj +2 more sources